Wang Huafeng, Zhang Lijuan, Yang Luhong, Liu Chengfang, Zhang Qi, Zhang Linjing
Modern College of Arts and Science, or School of Life Science, Shanxi Normal University, Linfen, China.
Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Oncotarget. 2017 Mar 14;8(11):18486-18496. doi: 10.18632/oncotarget.14474.
By phagocytosing cancer cells and their cellular debris, macrophages play a critical role in nonspecific defense (innate immunity) and, as antigen presenters, they help initiate specific defense mechanisms (adaptive immunity). Malignant melanoma is a lethal disease due to its aggressive capacity for metastasis and resistance to therapy. For decades, considerable effort has gone into development of an effective immunotherapy for treatment of metastatic melanoma. In this review, we focus on the anti-tumor activities of macrophages in melanoma and their potential as therapeutic targets in melanoma. Although macrophages can be re-educated through intercellular signaling to promote tumor survival owing to their plasticity, we expect that targeting the anti-tumor activity of macrophages remains a promising strategy for melanoma inhibition. The combination of tumoricidal macrophage activation and other treatments such as surgery, chemotherapy, and radiotherapy, may provide an effective and comprehensive anti-melanoma strategy.
通过吞噬癌细胞及其细胞碎片，巨噬细胞在非特异性防御（固有免疫）中发挥关键作用，并且作为抗原呈递细胞，它们有助于启动特异性防御机制（适应性免疫）。恶性黑色素瘤是一种致命疾病，因其具有强大的转移能力和对治疗的抗性。几十年来，人们投入了大量精力来开发治疗转移性黑色素瘤的有效免疫疗法。在这篇综述中，我们聚焦于巨噬细胞在黑色素瘤中的抗肿瘤活性及其作为黑色素瘤治疗靶点的潜力。尽管巨噬细胞因其可塑性可通过细胞间信号传导进行重新编程以促进肿瘤存活，但我们预期靶向巨噬细胞的抗肿瘤活性仍是抑制黑色素瘤的一种有前景的策略。杀伤性巨噬细胞激活与手术、化疗和放疗等其他治疗方法相结合，可能会提供一种有效且全面的抗黑色素瘤策略。
