Zhou Qiujun, Fang Tingting, Wei Shenyu, Chai Shiqian, Yang Huifeng, Tao Maocan, Cao Yi
Department of First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310000, P.R. China.
Department of Hepato-Pancreato-Biliary Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310000, P.R. China.
Exp Ther Med. 2022 Aug 26;24(4):640. doi: 10.3892/etm.2022.11577. eCollection 2022 Oct.
Melanoma, which evolves from melanocytes, is the most malignant skin cancer and is highly fatal, although it only accounts for 4% of all skin cancers. Numerous studies have demonstrated that melanoma has a large tumor mutational burden, which means that melanoma has great potential to achieve immune evasion. Tumor-associated macrophages (TAMs) are an important component of both the immune system and tumor microenvironment. Several studies have demonstrated their double-edged sword effects on melanoma. The present review focuses on the role of TAMs in melanoma development, including regulation of proliferation, invasion, metastasis, angiogenesis and chemical resistance of melanoma. Furthermore, the existing mechanisms of action of the TAM-targeting treatments for melanoma are reviewed. More broadly, the weak points of existing research and the direction of future research are finally identified and described.
黑色素瘤起源于黑素细胞，是最恶性的皮肤癌，致死率很高，尽管它仅占所有皮肤癌的4%。大量研究表明，黑色素瘤具有很高的肿瘤突变负荷，这意味着黑色素瘤具有很强的免疫逃逸潜力。肿瘤相关巨噬细胞（TAM）是免疫系统和肿瘤微环境的重要组成部分。多项研究表明它们对黑色素瘤具有双刃剑效应。本综述重点关注TAM在黑色素瘤发展中的作用，包括对黑色素瘤增殖、侵袭、转移、血管生成和化学抗性的调节。此外，还综述了针对黑色素瘤的TAM靶向治疗的现有作用机制。更广泛地说，最终确定并描述了现有研究的薄弱点和未来研究的方向。
