Liu Yingzi, Mostafaei Farshad, Sowers Daniel, Hsieh Mindy, Zheng Wei, Nie Linda H
School of Health Sciences, Purdue University, West Lafayette, United States of America.
Physiol Meas. 2017 Mar;38(3):452-465. doi: 10.1088/1361-6579/aa577b. Epub 2017 Jan 6.
In the US alone, millions of workers, including over 300 000 welders, are at high risk of occupational manganese (Mn) exposure. Those who have been chronically exposed to excessive amount of Mn can develop severe neurological disorders similar, but not identical, to the idiopathic Parkinson's disease. One challenge of identifing the health effects of Mn exposure is to find a reliable biomarker for exposure assessment, especially for long-term cumulative exposure.
Mn's long biological half-life as well as its relatively high concentration in bone makes bone Mn (BnMn) a potentially valuable biomarker for Mn exposure. Our group has been working on the development of a deuterium-deuterium (D-D)-based neutron generator to quantify Mn in bone in vivo. Main results and significance: In this paper, we report the latest advancements in our system. With a customized hand irradiation assembly, a fully characterized high purity germanium (HPGe) detector system, and an acceptable hand dose of 36 mSv, a detection limit of 0.64 µg Mn/g bone (ppm) has been achieved.
仅在美国，就有数百万人，包括超过30万名焊工，面临职业性锰（Mn）暴露的高风险。那些长期接触过量锰的人可能会患上与特发性帕金森病相似但不完全相同的严重神经疾病。确定锰暴露对健康影响的一个挑战是找到一种可靠的生物标志物用于暴露评估，特别是对于长期累积暴露。
锰的生物半衰期长，且在骨骼中的浓度相对较高，这使得骨锰（BnMn）成为一种潜在的有价值的锰暴露生物标志物。我们团队一直在致力于开发一种基于氘 - 氘（D - D）的中子发生器，以在体内定量骨骼中的锰。主要结果及意义：在本文中，我们报告了我们系统的最新进展。通过定制的手部照射组件、经过充分表征的高纯锗（HPGe）探测器系统，以及36 mSv的可接受手部剂量，实现了0.64 μg Mn/g骨（ppm）的检测限。
