Paldi A, Nagy A, Markkula M, Barna I, Dezso L
Agricultural Biotechnology Center, Godollo, Hungary.
Development. 1989 Jan;105(1):115-8. doi: 10.1242/dev.105.1.115.
Chimeras were made from parthenogenetic and fertilized cleavage-stage mouse embryos. The perinatal mortality was high. The parthenogenetic contributions to different tissues at birth ranged from 0 to 50%. No selection of parthenogenetic cells was observed in the pigmentation of the coat, but this does not exclude that such selection could act in other tissues. The weight of chimeras at birth negatively correlated to the average contribution of the parthenogenetic part. The growth rate of chimeras was lower than that of nonchimeric animals. The data presented demonstrated that, although parthenogenetic cells are not cell lethals and they can participate to some degree in normal development of most tissues, their extensive presence reduces the viability of chimeras and retards the postnatal development.
嵌合体由孤雌生殖和受精的卵裂期小鼠胚胎构建而成。围产期死亡率很高。出生时孤雌生殖细胞对不同组织的贡献范围为0%至50%。在被毛色素沉着中未观察到对孤雌生殖细胞的选择，但这并不排除这种选择可能在其他组织中起作用。嵌合体出生时的体重与孤雌生殖部分的平均贡献呈负相关。嵌合体的生长速度低于非嵌合体动物。所呈现的数据表明，尽管孤雌生殖细胞并非细胞致死性的，并且它们可以在一定程度上参与大多数组织的正常发育，但其大量存在会降低嵌合体的活力并阻碍出生后的发育。
