Dagistan Yasar, Cukur Selma, Dagistan Emine, Gezici Ali Riza
Department of Neurosurgery, Abant Izzet Baysal University Medical School, Izzet Baysal Training and Research Hospital, Bolu, Turkey.
Department of Pathology, Abant Izzet Baysal University Medical School, Izzet Baysal Training and Research Hospital, Bolu, Turkey.
J Korean Neurosurg Soc. 2017 Jan 1;60(1):40-46. doi: 10.3340/jkns.2015.0911.002. Epub 2016 Dec 29.
To assess role of some inflammatory mediators in patients with primary and recurrent lumbar disc herniation. Expression of IL-6, transforming growth factor (TGF)-1, insulin-like growth factor (IGF)-1, and Bcl-2-associated X protein (BAX) have been shown to be more intense in the primary group than the recurrent goup, but this mediators may be important aspects prognostic.
19 patients underwent primary and revision operations between June 1, 2009 and June 1, 2014, and they were included in this study. The 19 patients' intervertebral disc specimens obtained from the primary procedures and reoperations were evaluated. Expression of IL-6, TGF-1, IGF-1, and BAX were examined immunohistochemically in the 38 biopsy tissues obtained from the primary and recurrent herniated intervertebral discs during the operation.
For IL-6 expression in the intervertebral disc specimens, there was no difference between the groups. The immunohistochemical study showed that the intervertebral disc specimens in the primary group were stained intensely by TGF-1 compared with the recurrent group. Expression of IGF-1 in the primary group was found moderate. In contrast, in the recurrent group of patients was mild expression of IGF-1. The primary group intervertebral disc specimens were stained moderately by BAX compared with the recurrent group.
The results of our prognostic evaluation of patients in the recurrent group who were operated due to disc herniation suggest that mediators may be important parameters.
评估某些炎症介质在原发性和复发性腰椎间盘突出症患者中的作用。白细胞介素-6（IL-6）、转化生长因子（TGF）-1、胰岛素样生长因子（IGF）-1和Bcl-2相关X蛋白（BAX）的表达在原发性组中比复发性组更为强烈，但这些介质可能是预后的重要方面。
2009年6月1日至2014年6月1日期间，19例患者接受了初次手术和翻修手术，并被纳入本研究。对从初次手术和再次手术中获取的19例患者的椎间盘标本进行评估。在手术过程中，从原发性和复发性椎间盘突出症患者获取的38块活检组织中，采用免疫组织化学方法检测IL-6、TGF-1、IGF-1和BAX的表达。
对于椎间盘标本中IL-6的表达，两组之间没有差异。免疫组织化学研究表明，与复发性组相比，原发性组的椎间盘标本被TGF-1强烈染色。原发性组中IGF-1的表达中等。相比之下，复发性组患者中IGF-1的表达较弱。与复发性组相比，原发性组的椎间盘标本被BAX中度染色。
我们对因椎间盘突出症接受手术的复发性组患者进行预后评估的结果表明，这些介质可能是重要的参数。
