用于单分子相关纳米操作与共定位（NanoCOSM）的DNA底物及功能化玻璃表面的制备
Preparation of DNA Substrates and Functionalized Glass Surfaces for Correlative Nanomanipulation and Colocalization (NanoCOSM) of Single Molecules.
作者信息
Duboc C, Fan J, Graves E T, Strick T R
机构信息
Institut Jacques Monod, Centre National de la Recherche Scientifique, University of Paris Diderot and Sorbonne Paris Cité, Paris, France.
Institut Jacques Monod, Centre National de la Recherche Scientifique, University of Paris Diderot and Sorbonne Paris Cité, Paris, France; Ecole Normale Supérieure, Institut de Biologie de l'ENS (iBENS), INSERM, CNRS, PSL Research University, Paris, France.
出版信息
Methods Enzymol. 2017;582:275-296. doi: 10.1016/bs.mie.2016.09.048. Epub 2016 Dec 3.
Simultaneous nanomanipulation and colocalization of single molecules (NanoCOSM) provides a unique opportunity to correlate the mechanical properties and activities of biomolecules with their conformational states or states of assembly as part of dynamic macromolecular complexes. This opens the door to real-time single-molecule analysis of the correlations between structure, function, and composition of large multicomponent protein complexes.
单分子同时纳米操纵与共定位技术（NanoCOSM）提供了一个独特的机会，可将生物分子的力学性质和活性与其构象状态或作为动态大分子复合物一部分的组装状态相关联。这为实时单分子分析大型多组分蛋白质复合物的结构、功能和组成之间的相关性打开了大门。
Zotero 插件