Oliveira Ezequiel Fernandes, Nacif Sergio Roberto, Urbano Jessica Julioti, Silva Anderson Soares, Oliveira Claudia Santos, Perez Eduardo Araujo, Polaro Melissa Nunes, Valerio Berenice Cataldo Oliveira, Stirbulov Roberto, Insalaco Giuseppe, Oliveira Acary Sousa Bulle, Oliveira Luis Vicente Franco
Sleep Laboratory, Rehabilitation Sciences Master's and PhD Degree Program, Nove de Julho University - UNINOVE, Sao Paulo, SP, Brazil.
Department of Doenças do Aparelho Respiratório, Instituto de Assistência Medica do Servidor Publico Estadual - IAMSPE, Sao Paulo, SP, Brazil.
Neuromuscul Disord. 2017 Feb;27(2):120-127. doi: 10.1016/j.nmd.2016.11.015. Epub 2016 Nov 25.
The purpose of this study was to investigate the physiological variables of lung function, respiratory muscle strength, and sleep in clinically stable patients with myasthenia gravis. This was a prospective cross-sectional study conducted in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement. Patients adhering to the eligibility criteria were consecutively recruited from the Research Department of Neuromuscular Diseases at the Federal University of Sao Paulo and the Department of Neurology at Santa Casa de Misericordia of Sao Paulo and were referred to the Nove de Julho University Sleep Laboratory (Sao Paulo, Brazil). The study included 25 patients (21 female) with a mean age of 45.28 ± 12.33 years. Only one patient exhibited a restrictive ventilatory pattern. The maximum ventilatory pressures observed were considerably reduced in most patients as compared to reference values. In sleep studies, the patients exhibited significantly reduced oxygen saturation, reduced rapid eye movement sleep time, increased non-rapid eye movement stage 3 sleep, and considerable apnoea/hypopnoea indexes. Clinically stable patients with myasthenia gravis exhibit a high prevalence of sleep-disordered breathing, significant reductions in maximum ventilatory pressures, and impairment of health-related quality of life.
本研究的目的是调查临床病情稳定的重症肌无力患者的肺功能、呼吸肌力量和睡眠等生理变量。这是一项按照《加强流行病学观察性研究报告规范》（STROBE）声明进行的前瞻性横断面研究。符合入选标准的患者连续从圣保罗联邦大学神经肌肉疾病研究部和圣保罗圣卡塔琳娜慈善医院神经内科招募，并被转至七月九日大学睡眠实验室（巴西圣保罗）。该研究纳入了25例患者（21例女性），平均年龄为45.28±12.33岁。只有1例患者表现出限制性通气模式。与参考值相比，大多数患者观察到的最大通气压力显著降低。在睡眠研究中，患者的血氧饱和度显著降低，快速眼动睡眠时间减少，非快速眼动3期睡眠时间增加，呼吸暂停/低通气指数相当高。临床病情稳定的重症肌无力患者睡眠呼吸障碍患病率高，最大通气压力显著降低，与健康相关的生活质量受损。
