Speca Silvia, Dubuquoy Laurent
Lille Inflammation Research International Center (LIRIC), U995, University Lille, Inserm, CHU Lille, 59000 Lille, France.
Lille Inflammation Research International Center (LIRIC), U995, University Lille, Inserm, CHU Lille, 59000 Lille, France.
Joint Bone Spine. 2017 Jul;84(4):417-420. doi: 10.1016/j.jbspin.2016.12.016. Epub 2017 Jan 3.
Bowel inflammation is closely linked to chronic joint inflammation. Research reported in the 1980s demonstrated bowel inflammation with gross and microscopic pathological features identical to those of Crohn's disease in over 60% of patients with spondyloarthritis (SpA). Numerous prospective studies have evidenced joint involvement in patients with chronic inflammatory bowel disease (IBD) and bowel inflammation in patients with SpA. Nevertheless, the interactions of joint disease and chronic bowel inflammation remain incompletely elucidated. Two main hypotheses have been suggested to explain potential links between inflammation of the mucosal immune system and peripheral arthritis: one identifies gut bacteria as potentially implicated in the development of joint inflammation and the other involves the recruitment of gut lymphocytes or activated macrophages to the joints. Pathophysiological investigations have established that HLA-B27 is a pivotal pathogenic factor. Here, we review current data on links between chronic bowel inflammation and inflammatory joint disease.
肠道炎症与慢性关节炎症密切相关。20世纪80年代报道的研究表明，超过60%的脊柱关节炎（SpA）患者存在肠道炎症，其大体和微观病理特征与克罗恩病相同。众多前瞻性研究已证实，慢性炎症性肠病（IBD）患者会出现关节受累，而SpA患者会出现肠道炎症。然而，关节疾病与慢性肠道炎症之间的相互作用仍未完全阐明。为了解释黏膜免疫系统炎症与外周关节炎之间的潜在联系，人们提出了两种主要假说：一种认为肠道细菌可能与关节炎症的发生有关，另一种则涉及肠道淋巴细胞或活化巨噬细胞向关节的募集。病理生理学研究已证实，HLA - B27是一个关键的致病因素。在此，我们综述了关于慢性肠道炎症与炎性关节疾病之间联系的现有数据。
