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改良式冰冻象鼻术治疗急性A型主动脉夹层:与标准修复技术的对比研究

Modified frozen elephant trunk for acute type A aortic dissection: a comparative study with standard repair technique.

作者信息

Matt Peter, Banerjee Prerana, Grapow Martin, Rueter Florian, Schurr Ulrich, Siegemund Martin, Fassl Jens, Reuthebuch Oliver, Eckstein Friedrich

机构信息

Division of Cardiac Surgery, University Hospital Basel, Basel, Switzerland.

Department of Anesthesiology and Intensive Care Medicine, University Hospital Basel, Basel, Switzerland.

出版信息

Eur J Cardiothorac Surg. 2017 Apr 1;51(4):754-760. doi: 10.1093/ejcts/ezw412.

Abstract

OBJECTIVES

We hypothesized that antegrade open stent graft implantation in the descending aorta during acute type A aortic dissection surgery is safe and improves patient outcome compared with the standard repair technique.

METHODS

Hundred and forty-one consecutive patients underwent surgery for acute type A aortic dissection at our institution from 2010 to 2016. Of those, 104 patients underwent ascending aorta and hemiarch repair under hypothermic circulatory arrest with antegrade cerebral perfusion (standard group). Since 2013, 37 patients have undergone the standard procedure combined with antegrade stent implantation in the descending aorta (stented group). A matched analysis using the logistic EuroSCORE (37 patients per group) was done. All data were collected prospectively.

RESULTS

The mean logistic EuroSCORE was 29 in both groups, P  =   1. Cardiopulmonary bypass time was 150 ± 57 (standard) vs 157 ± 48 (stented) min, P  =   0.6; aortic clamping 99 ± 47 (standard) vs 100 ± 36 (stented) min, P  =   1. Stented patients had longer circulatory arrest times with antegrade cerebral perfusion, 23 ± 7 vs 15 ± 7 min, P  <   0.001. Stroke occurred in 24.3% (standard) vs 8.1% (stented), P  =   0.1; paraplegia developed in 2.7% (standard) vs 0% (stented), P  =   1. Abdominal intervention due to suspected visceral ischaemia was needed in 18.9% (standard) vs 5.4% (stented), P  =   0.2. 30-day mortality was 13.5% (standard) vs 0% (stented), P  =   0.05. Survival at 6-month was 100% and 86.5% in patients with implanted stents and standard repair, respectively, P  =   0.02.

CONCLUSIONS

Antegrade, open stent graft implantation into the descending aorta during acute type A aortic dissection repair is safe and is associated with improved outcomes at 6 months postoperatively compared to the standard repair technique.

摘要

目的

我们假设在急性A型主动脉夹层手术期间,在降主动脉内进行顺行开放式支架植入术是安全的,并且与标准修复技术相比能改善患者预后。

方法

2010年至2016年期间,我院141例连续患者接受了急性A型主动脉夹层手术。其中,104例患者在低温循环停搏和顺行脑灌注下进行升主动脉和半弓修复(标准组)。自2013年以来,37例患者接受了标准手术并在降主动脉内进行顺行支架植入(支架组)。使用逻辑欧洲心脏手术风险评估系统(每组37例患者)进行匹配分析。所有数据均前瞻性收集。

结果

两组的平均逻辑欧洲心脏手术风险评估系统评分为29,P = 1。体外循环时间为150±57(标准组)对157±48(支架组)分钟,P = 0.6;主动脉阻断时间为99±47(标准组)对100±36(支架组)分钟,P = 1。支架植入患者在顺行脑灌注下的循环停搏时间更长,分别为23±7分钟对15±7分钟,P < 0.001。中风发生率在标准组为24.3%,支架组为8.1%,P = 0.1;截瘫发生率在标准组为2.7%,支架组为0%,P = 1。因疑似内脏缺血而需要进行腹部干预的发生率在标准组为18.9%,支架组为5.4%,P = 0.2。30天死亡率在标准组为13.5%,支架组为0%,P = 0.05。植入支架患者和标准修复患者6个月时的生存率分别为100%和86.5%,P = 0.02。

结论

在急性A型主动脉夹层修复术中,在降主动脉内进行顺行开放式支架植入术是安全的,并且与标准修复技术相比,术后6个月时预后得到改善。

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