Wang Weiye, Zhong Chunrong, Huang Li, Zhou Xuezhen, Chen Renjuan, Wu Jiangyue, Li Xiating, Xiong Ting, Liu Chaoqun, Xiao Mei, Yang Xuefeng, Hao Liping, Yang Nianhong, Wei Sheng
Department of Epidemiology and Biostatistics, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Occup Environ Med. 2017 Mar;74(3):204-210. doi: 10.1136/oemed-2016-103980. Epub 2017 Jan 6.
To examine the relationship between prenatal nitrogen dioxide (NO) exposure and foetal growth in a prospective cohort of 1001 Chinese women.
The maternal NO exposure levels were estimated using land-use regression models based on home address. The biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC), femur length (FL) and estimated foetal weight (EFW) were evaluated via ultrasonography. The multiple linear regression model was used to adjust for confounders, and the mixed-effect model was used to assess longitudinal effect.
With a 10 μg/m increase in NO exposure, the BPD, HC, AC, FL and EFW in the second trimester decreased by 0.40 mm (95% CI -0.56 to -0.24), 1.07 mm (95% CI -1.60 to -0.54), 1.02 mm (95% CI -1.57 to -0.48), 0.24 mm (95% CI -0.37 to -0.12) and 7.84 g (95% CI -11.59 to -4.08), respectively; the BPD and HC in the third trimester decreased by 0.26 mm (95% CI -0.50 to -0.02) and 0.71 mm (95% CI -1.37 to -0.06), respectively. The longitudinal analyses showed inverse associations of NO exposure with BPD, HC, AC and FL (all p<0.05). The stratified analyses showed that the effects of NO on the HC, FL and EFW in the second trimester were stronger among female babies and that the effect of NO on EFW in the third trimester was stronger among smoking mothers (all p<0.05).
In this prospective study of Chinese women, maternal NO exposure was inversely associated with foetal growth, and the association was stronger among female babies and smoking mothers.
在1001名中国女性的前瞻性队列研究中，探讨孕期二氧化氮（NO）暴露与胎儿生长之间的关系。
根据家庭住址，采用土地利用回归模型估算母亲的NO暴露水平。通过超声检查评估双顶径（BPD）、头围（HC）、腹围（AC）、股骨长度（FL）和估计胎儿体重（EFW）。使用多元线性回归模型调整混杂因素，并使用混合效应模型评估纵向效应。
NO暴露每增加10μg/m，孕中期的BPD、HC、AC、FL和EFW分别下降0.40mm（95%CI -0.56至-0.24）、1.07mm（95%CI -1.60至-0.54）、1.02mm（95%CI -1.57至-于0.48）、0.24mm（95%CI -0.37至-0.12）和7.84g（95%CI -11.59至-4.08）；孕晚期的BPD和HC分别下降0.26mm（95%CI -0.50至-0.02）和0.71mm（95%CI -1.37至-0.06）。纵向分析显示，NO暴露与BPD、HC、AC和FL呈负相关（所有p<0.05）。分层分析显示，NO对孕中期女婴的HC、FL和EFW的影响更强，NO对孕晚期吸烟母亲的EFW的影响更强（所有p<0.05）。
在这项针对中国女性的前瞻性研究中，母亲的NO暴露与胎儿生长呈负相关，且这种关联在女婴和吸烟母亲中更强。
