Law N W, Ellis H
Professorial Surgical Unit, Westminster Hospital, London, UK.
Eur Surg Res. 1989;21(3-4):218-23. doi: 10.1159/000129027.
The effect of a low-protein diet on the healing of colonic anastomoses in the rat was studied. The low-protein diet given for 2 weeks caused a weight loss of 11.9%. The healing of colonic anastomoses was assessed by bursting pressure measurement performance sequentially in the postoperative period. Compared to control animals, rats on a low-protein diet had significantly lower bursting pressures from the 4th to the 7th postoperative day. There was no difference in the hydroxyproline concentration at the anastomoses of the two groups of rats. These results suggest that the 5th postoperative day is the most appropriate time to investigate the effects of protein malnutrition on colonic healing in the rat.
研究了低蛋白饮食对大鼠结肠吻合口愈合的影响。给予低蛋白饮食2周导致体重减轻11.9%。在术后期间，通过依次测量爆破压力来评估结肠吻合口的愈合情况。与对照动物相比，低蛋白饮食的大鼠在术后第4天至第7天的爆破压力明显较低。两组大鼠吻合口处的羟脯氨酸浓度没有差异。这些结果表明，术后第5天是研究蛋白质营养不良对大鼠结肠愈合影响的最合适时间。
