Molfino Alessio, Amabile Maria Ida, Ammann Thomas, Farcomeni Alessio, Lionetto Luana, Simmaco Maurizio, Lai Silvia, Laviano Alessandro, Rossi Fanelli Filippo, Chiappini Maria Grazia, Muscaritoli Maurizio
Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy.
Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy.
Nutrition. 2017 Feb;34:101-107. doi: 10.1016/j.nut.2016.07.012. Epub 2016 Jul 30.
Physical inactivity is frequent in patients on hemodialysis (HD), and represents a reliable predictor of morbidity and mortality. Beta-aminoisobutyric acid (BAIBA) is a contraction-induced myokine, the plasma levels of which increase with exercise and are inversely associated with metabolic risk factors. The aim of this study was to ascertain whether physical inactivity and clinical parameters relate to plasma BAIBA levels in this patient population.
Adult patients on HD were included, and the presence of physical inactivity was assessed. BAIBA levels were measured in these patients and in healthy individuals. We assessed barriers to physical activity, including 23 items regarding psychophysical and financial barriers. Body composition was assessed by bioimpedance and muscle strength by handgrip dynamometer. Nonparametric tests and logistic regression analyses were performed.
Forty-nine patients on HD were studied; 49% were physically active and 51% were inactive. Of the patients, 43 reported barriers to physical activity and 61% of inactive patients reported three or more barriers. BAIBA levels were lower in patients on HD with respect to controls (P < 0.001). Stratifying HD patients as active and inactive, both groups showed significantly lower BAIBA levels versus controls (P = 0.0005, P < 0.001, respectively). Nondiabetic patients on HD showed increased BAIBA levels compared with diabetic patients (P < 0.001). Patients on HD endorsing the two most frequent barriers showed lower BAIBA levels than those not reporting these barriers (P = 0.006). Active patients showed higher intracellular water (%) (P = 0.008), and active and inactive patients showed significant correlation between total body muscle mass and handgrip strength (P = 0.04, P = 0.005, respectively).
Physical inactivity is highly prevalent among patients on HD and BAIBA correlates with barriers to physical activity reported by inactive patients.
血液透析（HD）患者经常缺乏身体活动，这是发病率和死亡率的可靠预测指标。β-氨基异丁酸（BAIBA）是一种运动诱导的肌动蛋白，其血浆水平随运动增加，且与代谢危险因素呈负相关。本研究的目的是确定在该患者群体中，缺乏身体活动和临床参数是否与血浆BAIBA水平相关。
纳入成年HD患者，评估其缺乏身体活动的情况。测量这些患者及健康个体的BAIBA水平。我们评估了身体活动的障碍，包括23项关于心理生理和经济障碍的项目。通过生物电阻抗评估身体成分，通过握力计评估肌肉力量。进行非参数检验和逻辑回归分析。
研究了49例HD患者；49%身体活动，51%缺乏身体活动。其中，43例患者报告了身体活动的障碍，61%缺乏身体活动的患者报告了三种或更多障碍。HD患者的BAIBA水平低于对照组（P < 0.001）。将HD患者分为活动组和非活动组，两组的BAIBA水平均显著低于对照组（分别为P = 0.0005，P < 0.001）。HD非糖尿病患者的BAIBA水平高于糖尿病患者（P < 0.001）。认可两种最常见障碍的HD患者的BAIBA水平低于未报告这些障碍的患者（P = 0.006）。活动患者的细胞内水含量较高（P = 0.008），活动和非活动患者的全身肌肉质量与握力之间存在显著相关性（分别为P = 0.04，P = 0.005）。
HD患者中缺乏身体活动的情况非常普遍，且BAIBA与非活动患者报告的身体活动障碍相关。
