Yu N Y, Wolfson T, Middleton M S, Hamilton G, Gamst A, Angeles J E, Schwimmer J B, Sirlin C B
Liver Imaging Group, Department of Radiology, University of California, San Diego School of Medicine, San Diego, CA, USA.
Computational and Applied Statistics Laboratory, San Diego Supercomputer Center, University of California, San Diego, La Jolla, CA, USA.
Clin Radiol. 2017 May;72(5):425.e9-425.e14. doi: 10.1016/j.crad.2016.11.017. Epub 2017 Jan 5.
To investigate the relationship between bone marrow fat content and hepatic fat content in children with known or suspected non-alcoholic fatty liver disease (NAFLD).
This was an institutional review board-approved, Health Insurance Portability and Accountability Act (HIPAA)-compliant, cross-sectional, prospective analysis of data collected between October 2010 to March 2013 in 125 children with known or suspected NAFLD. Written informed consent was obtained for same-day research magnetic resonance imaging (MRI) of the lumbar spine, liver, and abdominal adiposity. Lumbar spine bone marrow proton density fat fraction (PDFF) and hepatic PDFF were estimated using complex-based MRI (C-MRI) techniques and magnitude-based MRI (M-MRI), respectively. Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SCAT) were quantified using high-resolution MRI. All images were acquired by two MRI technologists. Hepatic M-MRI images were analysed by an image analyst; all other images were analysed by a single investigator. The relationship between lumbar spine bone marrow PDFF and hepatic PDFF was assessed with and without adjusting for the presence of covariates using correlation and regression analysis.
Lumbar spine bone marrow PDFF was positively associated with hepatic PDFF in children with known or suspected NAFLD prior to adjusting for covariates (r=0.33, p=0.0002). Lumbar spine bone marrow PDFF was positively associated with hepatic PDFF in children with known or suspected NAFLD (r=0.24, p=0.0079) after adjusting for age, sex, body mass index z-score, VAT, and SCAT in a multivariable regression analysis.
Bone marrow fat content is positively associated with hepatic fat content in children with known or suspected NAFLD. Further research is needed to confirm these results and understand their clinical and biological implications.
探讨已知或疑似非酒精性脂肪性肝病（NAFLD）儿童的骨髓脂肪含量与肝脏脂肪含量之间的关系。
这是一项经机构审查委员会批准、符合《健康保险流通与责任法案》（HIPAA）的横断面前瞻性分析，对2010年10月至2013年3月期间收集的125例已知或疑似NAFLD儿童的数据进行分析。获得了同日对腰椎、肝脏和腹部脂肪进行研究性磁共振成像（MRI）的书面知情同意书。分别使用基于复数的MRI（C-MRI）技术和基于幅值的MRI（M-MRI）估算腰椎骨髓质子密度脂肪分数（PDFF）和肝脏PDFF。使用高分辨率MRI对内脏脂肪组织（VAT）和皮下脂肪组织（SCAT）进行定量。所有图像均由两名MRI技术人员采集。肝脏M-MRI图像由一名图像分析师分析；所有其他图像由一名研究人员分析。使用相关性和回归分析，在调整协变量存在与否的情况下，评估腰椎骨髓PDFF与肝脏PDFF之间的关系。
在调整协变量之前，已知或疑似NAFLD儿童的腰椎骨髓PDFF与肝脏PDFF呈正相关（r = 0.33，p = 0.0002）。在多变量回归分析中调整年龄、性别、体重指数z评分、VAT和SCAT后，已知或疑似NAFLD儿童的腰椎骨髓PDFF与肝脏PDFF仍呈正相关（r = 0.24，p = 0.0079）。
已知或疑似NAFLD儿童的骨髓脂肪含量与肝脏脂肪含量呈正相关。需要进一步研究以证实这些结果并了解其临床和生物学意义。
