Achmad Emil, Yokoo Takeshi, Hamilton Gavin, Heba Elhamy R, Hooker Jonathan C, Changchien Christopher, Schroeder Michael, Wolfson Tanya, Gamst Anthony, Schwimmer Jeffrey B, Lavine Joel E, Sirlin Claude B, Middleton Michael S
Liver Imaging Group, Department of Radiology, School of Medicine, University of California, San Diego, San Diego, CA, USA.
Department of Radiology and Advanced Imaging Research Center, UT Southwestern School of Medicine, Dallas, TX, USA.
Abdom Imaging. 2015 Oct;40(8):3084-90. doi: 10.1007/s00261-015-0506-9.
To assess feasibility of and agreement between magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) for estimating hepatic proton density fat fraction (PDFF) in children with known or suspected nonalcoholic fatty liver disease (NAFLD).
Children were included in this study from two previous research studies in each of which three MRI and three MRS acquisitions were obtained. Sequence acceptability, and MRI- and MRS-estimated PDFF were evaluated. Agreement of MRI- with MRS-estimated hepatic PDFF was assessed by linear regression and Bland-Altman analysis. Age, sex, BMI-Z score, acquisition time, and artifact score effects on MRI- and MRS-estimated PDFF agreement were assessed by multiple linear regression.
Eighty-six children (61 boys and 25 girls) were included in this study. Slope and intercept from regressing MRS-PDFF on MRI-PDFF were 0.969 and 1.591%, respectively, and the Bland-Altman bias and 95% limits of agreement were 1.17% ± 2.61%. MRI motion artifact score was higher in boys than girls (by 0.21, p = 0.021). Higher BMI-Z score was associated with lower agreement between MRS and MRI (p = 0.045).
Hepatic PDFF estimation by both MRI and MRS is feasible, and MRI- and MRS-estimated PDFF agree closely in children with known or suspected NAFLD.
评估磁共振成像（MRI）和磁共振波谱（MRS）在估计已知或疑似非酒精性脂肪性肝病（NAFLD）儿童肝脏质子密度脂肪分数（PDFF）方面的可行性及一致性。
本研究纳入了来自之前两项研究的儿童，每项研究均获取了三次MRI和三次MRS扫描数据。评估序列可接受性以及MRI和MRS估计的PDFF。通过线性回归和Bland-Altman分析评估MRI与MRS估计的肝脏PDFF的一致性。通过多元线性回归评估年龄、性别、BMI-Z评分、采集时间和伪影评分对MRI和MRS估计的PDFF一致性的影响。
本研究纳入了86名儿童（61名男孩和25名女孩）。MRS-PDFF对MRI-PDFF回归的斜率和截距分别为0.969和1.591%，Bland-Altman偏差和95%一致性界限为1.17%±2.61%。男孩的MRI运动伪影评分高于女孩（高0.21，p = 0.021）。较高的BMI-Z评分与MRS和MRI之间较低的一致性相关（p = 0.045）。
MRI和MRS估计肝脏PDFF均可行，在已知或疑似NAFLD的儿童中，MRI和MRS估计的PDFF密切相关。
