Froehner Michael, Kuithan Friederike, Zöphel Klaus, Heberling Ulrike, Laniado Michael, Wirth Manfred P
Department of Urology, University Hospital "Carl Gustav Carus", Technische Universität Dresden, Dresden, Germany.
Department of Pathology, University Hospital "Carl Gustav Carus", Technische Universität Dresden, Dresden, Germany.
Urology. 2017 Mar;101:e5-e6. doi: 10.1016/j.urology.2016.11.040. Epub 2017 Jan 4.
A 68-year-old man presented with synchronous metastatic penile and prostate cancer. 68Ga-labeled prostate-specific membrane antigen-targeted ligand positron emission tomography/computed tomography (PSMA-PET/CT) revealed tracer uptake in inguinal, pelvic, and retroperitoneal metastases. Lymph node biopsies and immunohistochemical staining revealed that both cancers involved the lymph nodes and expressed PSMA. In the deposits of penile squamous cell carcinoma, PSMA expression was seen in tumor vessels and may explain the PSMA-PET/CT positivity of inguinal nodes involved in squamous cell carcinoma. The interpretation of imaging in synchronous tumors should take this fact into consideration.
一名68岁男性被诊断为同时患有转移性阴茎癌和前列腺癌。68Ga标记的前列腺特异性膜抗原靶向配体正电子发射断层扫描/计算机断层扫描（PSMA-PET/CT）显示，腹股沟、盆腔和腹膜后转移灶有示踪剂摄取。淋巴结活检和免疫组化染色显示，两种癌症均累及淋巴结并表达PSMA。在阴茎鳞状细胞癌的病灶中，PSMA表达于肿瘤血管，这可能解释了鳞状细胞癌累及的腹股沟淋巴结PSMA-PET/CT呈阳性的原因。在同步性肿瘤的影像学解读中应考虑这一事实。
