苏拉明对豚鼠盲肠带平滑肌细胞中P2嘌呤受体反应的抑制作用。
The inhibitory action of suramin on the P2-purinoceptor response in smooth muscle cells of guinea-pig taenia caeci.
作者信息
den Hertog A, Nelemans A, Van den Akker J
机构信息
Department of Pharmacology/Clinical Pharmacology, University of Groningen, The Netherlands.
出版信息
Eur J Pharmacol. 1989 Aug 3;166(3):531-4. doi: 10.1016/0014-2999(89)90370-1.
The effect of suramin on the smooth muscle cell response of guinea-pig taenia caeci to P2-purinoceptor and alpha 1-adrenoceptor stimulation was measured. The ATP-induced relaxation in potassium (20 mM) pre-contracted taenia caeci was inhibited by suramin (3 x 10(-4) M). The P2-purinoceptor-induced hyperpolarization elicited by ATP both in the presence and absence of calcium was also reduced by suramin. The alpha 1-adrenoceptor-mediated relaxation evoked by phenylephrine was only affected by suramin at low concentrations of the agonist. The results indicate that suramin inhibits the ATP response by interacting with P2y-purinoceptors.
测定了苏拉明对豚鼠盲肠带平滑肌细胞对P2嘌呤受体和α1肾上腺素能受体刺激的反应的影响。在钾离子（20 mM）预收缩的盲肠带中，ATP诱导的舒张被苏拉明（3×10⁻⁴ M）抑制。在有钙和无钙情况下，ATP引发的P2嘌呤受体诱导的超极化也被苏拉明降低。苯肾上腺素引发的α1肾上腺素能受体介导的舒张仅在低浓度激动剂时受苏拉明影响。结果表明，苏拉明通过与P2y嘌呤受体相互作用抑制ATP反应。
Zotero 插件