酮色林对离体灌流大鼠肺脏中血清素诱导的血管反应的影响。

The effect of ketanserin on serotonin-induced vascular responses in the isolated perfused rat lung.

作者信息

Le Roux M G, Syce J A

机构信息

Department of Pharmacology, School of Pharmacy, University of the Western Cape, Bellville, Cape Province, South Africa.

出版信息

Eur J Pharmacol. 1989 Oct 10;169(2-3):269-73. doi: 10.1016/0014-2999(89)90024-1.

DOI:10.1016/0014-2999(89)90024-1

PMID:2806384

Abstract

Based on a vasoconstrictor role for serotonin (5-HT) in various types of cardiopulmonary conditions the effect of the 5-HT2 receptor antagonist, ketanserin, on 5-HT-induced responses in the intact, isolated rat lung was investigated. 5-HT produced biphasic responses consisting of weak vasodilator and predominant, dose-dependent constrictor components. Ketanserin showed no direct vasodilator effects but could completely antagonise the 5-HT-induced vasoconstrictor responses, suggesting that this response was 5-HT2 receptor-mediated.

摘要

基于血清素（5-羟色胺，5-HT）在各类心肺疾病中具有血管收缩作用，研究了5-HT2受体拮抗剂酮色林对完整离体大鼠肺脏中5-HT诱导反应的影响。5-HT产生双相反应，包括微弱的血管舒张成分和主要的剂量依赖性收缩成分。酮色林未表现出直接的血管舒张作用，但能完全拮抗5-HT诱导的血管收缩反应，提示该反应是由5-HT2受体介导的。