Helgesen K G, Bjertnaes L
Int J Microcirc Clin Exp. 1986;5(1):65-72.
The pure and selective serotonin blocking agent ketanserin (5-HT2 receptor blocker) was used to evaluate a possible role for serotonin as a mediator of the pulmonary vasoconstrictor response to alveolar hypoxia. Isolated and ventilated lungs (FiO2 = 0.21) from rats were perfused at 310 degrees (K) with homologous blood at constant volume inflow, and pressor responses to standardized periods of ventilation hypoxia (FIO2 = 0.02) were recorded. Pressor responses to pulmonary arterial bolus-injections of serotonin were tested both before and after administration of ketanserin for comparison with the responses to hypoxia. We found that ketanserin in doses adequate to block the response to serotonin, had no effect on the pulmonary vasoconstrictor response to hypoxia.
使用纯的选择性5-羟色胺阻断剂酮色林（5-HT2受体阻断剂）来评估5-羟色胺作为对肺泡低氧血症的肺血管收缩反应介质的可能作用。将来自大鼠的离体且通气的肺（吸入氧分数=0.21）在310开尔文下以恒定的体积流入量用同源血液灌注，并记录对标准化通气低氧血症时期（吸入氧分数=0.02）的升压反应。在给予酮色林之前和之后，测试对肺动脉注射5-羟色胺的升压反应，以便与对低氧血症的反应进行比较。我们发现，足以阻断对5-羟色胺反应的剂量的酮色林，对肺血管对低氧血症的收缩反应没有影响。
