维生素 D 在肝脏疾病中的作用：现有证据和潜在方向。

Vitamin D in liver disease: Current evidence and potential directions.

机构信息

The Garvan Institute of Medical Research, The University of New South Wales (UNSW), Sydney, NSW, Australia.

The Garvan Institute of Medical Research, The University of New South Wales (UNSW), Sydney, NSW, Australia; The Westmead Institute of Medical Research, The University of Sydney, NSW, Australia.

出版信息

Biochim Biophys Acta Mol Basis Dis. 2017 Apr;1863(4):907-916. doi: 10.1016/j.bbadis.2017.01.001. Epub 2017 Jan 4.

DOI:10.1016/j.bbadis.2017.01.001

PMID:28064017

Abstract

Consistent with its multifaceted nature, growing evidence links vitamin D with hepatic disease. In this review, we summarise the roles of vitamin D in different liver pathologies and explore the clinical utility of vitamin D-based treatments in hepatology. We find that the small number of clinical trials coupled with the profound heterogeneity of study protocols limits the strength of evidence needed to ascribe definite clinical value to the hormone in liver disease. Nevertheless, the experimental data is promising and further bench and bedside studies will likely define a clearer role in hepatic therapeutics.

摘要

与维生素 D 的多效性一致，越来越多的证据表明其与肝脏疾病有关。在这篇综述中，我们总结了维生素 D 在不同肝脏疾病中的作用，并探讨了基于维生素 D 的治疗在肝病学中的临床应用。我们发现，由于临床试验数量较少，且研究方案的异质性较大，因此限制了将该激素在肝病中明确的临床价值归因于该激素的证据强度。尽管如此，实验数据还是很有前景的，进一步的基础和临床研究可能会明确其在肝脏治疗中的作用。