Department of Psychiatry, Charité Campus Mitte, Charitéplatz 1, D-10117, Berlin, Germany.
Department of Psychiatry, Charité Campus Mitte, Charitéplatz 1, D-10117, Berlin, Germany.
Psychiatry Res. 2017 Feb;248:140-146. doi: 10.1016/j.psychres.2016.12.030. Epub 2016 Dec 24.
In schizophrenia, processing of self-related stimuli has been shown to be altered. It is unclear whether altered self-processing in schizophrenia is confined to cognitive functions such as self-recognition, or whether it pertains to automatic lower-level perceptual processes. Visual face processing was tested in patients with schizophrenia (n=36) and healthy controls (n=33). Using a change detection paradigm (self, famous, unknown faces), we tested whether self-related stimuli gain access to awareness preferentially. The task was unrelated to face category, thus probing implicit processing of the face identity information. Furthermore we explored hemifield differences, the association of preferential self-processing with disease insight and with schizophrenic symptom severity. Change detection was overall enhanced for one's own face and familiar faces compared to unknown faces. There were no group differences regarding perception of self-related or familiar stimuli. The enhancing effect of self and familiarity on change detection was smaller in patients with more severe symptoms. We found no association between implicit visual self-perception and insight in schizophrenia. The privileged access of self-related visual information is not impaired in patients with schizophrenia. The reduced overall left-hemifield advantage for face-change detection points to an altered lateralization of face processing in patients with schizophrenia.
在精神分裂症中，与自我相关的刺激处理已被证明发生了改变。目前尚不清楚精神分裂症中的自我加工改变是否仅限于自我识别等认知功能，还是涉及到自动的较低层次的感知过程。对精神分裂症患者（n=36）和健康对照组（n=33）进行了视觉面部处理测试。使用变化检测范式（自我、知名、未知面孔），我们测试了自我相关刺激是否优先进入意识。该任务与面孔类别无关，因此可以探测面孔身份信息的内隐处理。此外，我们还探索了半视野差异，以及优先自我处理与疾病洞察力和精神分裂症症状严重程度的关联。与未知面孔相比，自身面孔和熟悉面孔的变化检测总体上增强。自身相关或熟悉刺激的感知在两组之间没有差异。症状更严重的患者的自我和熟悉感对变化检测的增强作用较小。我们没有发现精神分裂症中内隐视觉自我感知与洞察力之间存在关联。精神分裂症患者的自我相关视觉信息的优先访问不受损害。面孔变化检测的整体左半视野优势减小表明精神分裂症患者的面孔处理存在侧化改变。
