Gupta Neha, Singhal Divya, Singh Ashok Kumar, Singh Neetu, Singh U P
Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247667, India.
Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247667, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2017 Apr 5;176:38-46. doi: 10.1016/j.saa.2017.01.007. Epub 2017 Jan 4.
A colorimetric and fluorometric probe (E)-2-((8-hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)methylene)hydrazinecarbothioamide based on thiosemicarbazide and julolidine moieties has been synthesised in pure crystalline form and characterized by H NMR, UV-vis, elemental analysis and single crystal XRD. The probe functioned as multitarget ion sensor, detect biologically important metal ions Hg and Mn in dual channel mode. Meanwhile, in mixed solvent media DMF/HO [8:2], probe displayed selectivity for Hg over other cations by the emission spectrum. Interestingly probe has been explored to recognize F anion in DMF through ESIPT mechanism. The 1:1 binding stoichiometry of probe with Hg and Mn is confirmed by Job's plot through emission titration and UV-vis titration respectively. Probe is selective and sensitive to Hg and Mn with detection limit as low as 15μM and 0.2μM respectively. The sensing mechanism for selective ions was also scrutinized using H NMR experiments and computational studies.
基于氨基硫脲和呫吨酮部分合成了一种比色和荧光探针（E）-2-（（8-羟基-1,2,3,5,6,7-六氢吡啶并[3,2,1-ij]喹啉-9-基）亚甲基）肼基甲硫酰胺，其为纯晶体形式，并通过核磁共振氢谱、紫外可见光谱、元素分析和单晶X射线衍射进行了表征。该探针作为多目标离子传感器，以双通道模式检测具有生物学重要性的金属离子汞和锰。同时，在混合溶剂介质N,N-二甲基甲酰胺/水[8:2]中，该探针通过发射光谱对汞表现出相对于其他阳离子的选择性。有趣的是，该探针已被用于通过激发态分子内质子转移机制在N,N-二甲基甲酰胺中识别氟离子。通过分别通过发射滴定和紫外可见滴定的乔布图证实了探针与汞和锰的1:1结合化学计量比。该探针对汞和锰具有选择性和敏感性，检测限分别低至15μM和0.2μM。还使用核磁共振氢谱实验和计算研究仔细研究了选择性离子的传感机制。
