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Rockall风险评分对马来西亚人群30天非静脉曲张性上消化道再出血的预测作用

Rockall risk score in predicting 30 days non-variceal upper gastrointestinal rebleeding in a Malaysian population.

作者信息

Lip H T, Heah H T, Huei T J, Premaa S, Sarojah A

机构信息

Hospital Sultan Ismail, Department of Surgery, Jalan Persiaran Mutiara Emas Utama, 81100 Johor Bahru, Johor, Malaysia.

Hospital Sultanah Aminah, Clinical Research Centre, Malaysia.

出版信息

Med J Malaysia. 2016 Oct;71(5):225-230.

Abstract

OBJECTIVE

the aim of this study was to determine the usefulness of Rockall score in predicting outcomes of 30 days rebleeding, mortality and need for surgical intervention of bleeding gastric and duodenal ulcers.

METHODS

this is a retrospective cohort study of all the emergency endoscopies performed in Hospital sultan Ismail from January 2009 to October 2014 for indications of upper gastrointestinal bleeding (UGIb). Data was extracted from hospital's electronic database and only non-variceal bleeds were included. Rockall score was calculated and outcomes of 30 days rebleeding, mortality and need for surgery was recorded. For each outcome, calibration was done using the Goodness-of-fit tests and discriminative ability was reflected by area under the receiver operating characteristic curve (AUROc).

RESULTS

A total of 1323 patients were included with a male preponderance of 64%. the overall rates of rebleeding were 11.2%, mortality rate of 8.7% and need for surgery was 2%. Low AUROc values for rebleeding (0.63), mortality (0.58) and surgery (0.67) showed poor discriminative ability of Rockall score. the Goodness-of-fit test also revealed that the scoring system was poorly calibrated in outcomes of rebleeding (p <0.001), mortality (p = 0.001) and surgery (p = 0.038) with p-value <0.05. Patients with high risk (scores ≥8) displayed highest rebleeding and mortality rates of 20% respectively in comparison to the moderate (score 3-7) and low (score ≤2) risk groups.

CONCLUSION

Rockall score has a poor discriminative ability and is poorly calibrated for rebleeding, mortality and need for surgery in upper gastrointestinal bleeding. However, it is the best tool we have now to stratify patients into risk groups.

摘要

目的

本研究旨在确定罗卡尔评分在预测胃和十二指肠溃疡出血30天再出血、死亡率及手术干预需求方面的效用。

方法

这是一项回顾性队列研究,纳入了2009年1月至2014年10月在苏丹依斯迈医院因上消化道出血(UGIb)指征进行的所有急诊内镜检查。数据从医院电子数据库提取,仅纳入非静脉曲张性出血。计算罗卡尔评分,并记录30天再出血、死亡率及手术需求的结果。对于每个结果,使用拟合优度检验进行校准,判别能力通过受试者操作特征曲线下面积(AUROc)反映。

结果

共纳入1323例患者,男性占64%。再出血总发生率为11.2%,死亡率为8.7%,手术需求率为2%。再出血(0.63)、死亡率(0.58)和手术(0.67)的AUROc值较低,表明罗卡尔评分的判别能力较差。拟合优度检验还显示,该评分系统在再出血(p<0.001)、死亡率(p = 0.001)和手术(p = 0.038)结果中校准不佳,p值<0.05。与中度风险(评分3 - 7)和低风险(评分≤2)组相比,高风险(评分≥8)患者的再出血率和死亡率最高,分别为20%。

结论

罗卡尔评分在判别能力方面较差,在上消化道出血的再出血、死亡率及手术需求校准方面不佳。然而,它是我们目前将患者分层为风险组的最佳工具。

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