猴子巩膜静脉、施莱姆管和小梁网中的压力：眼压变化的影响。

The pressures in the episcleral veins, Schlemm's canal and the trabecular meshwork in monkeys: effects of changes in intraocular pressure.

作者信息

Mäepea O, Bill A

机构信息

Department of Physiology and Medical Biophysics, Uppsala University, Sweden.

出版信息

Exp Eye Res. 1989 Oct;49(4):645-63. doi: 10.1016/s0014-4835(89)80060-0.

DOI:10.1016/s0014-4835(89)80060-0

PMID:2806429

Abstract

The pressures in the episcleral veins, Schlemm's canal and the trabecular meshwork were studied with a micropuncture technique using cannulas with tip diameters of less than 5 microns. The pressure in Schlemm's canal, Psc, was 14.3 +/- 1.0 cmH2O at spontaneous intraocular pressure, IOP, 19.2 +/- 0.9 cmH2O. The outflow pressure from the anterior chamber to Schlemm's canal was 4.9 +/- 0.7 cmH2O. The relationship between pressures was IOP = 0.73 Psc + 8.7. When the intraocular pressure was increased stepwise from the spontaneous level to 30 cmH2O there was an increase in pressure in Schlemm's canal of 1.7 +/- 0.6 cmH2O, (P less than 0.05). The total outflow resistance and the resistance between the anterior chamber and Schlemm's canal were 3.27 +/- 0.43 and 2.92 +/- 0.50 cmH2O min microliter-1 respectively for the intraocular pressure interval between the spontaneous pressure and a level 4-11 cmH2O higher. In the intraocular pressure range from 20 to 30 cmH2O the corresponding figures were 2.89 +/- 0.45 and 2.69 +/- 0.42 cmH2O min microliter-1 and for the pressure range 25-35 cmH2O, 2.48 +/- 0.58 and 2.31 +/- 0.59 cmH2O min microliter-1. The difference between the total outflow resistance and that between the anterior chamber and Schlemm's canal was about 10% of the total at intraocular pressures below 35 cmH2O. Stepwise increments in IOP increased the trabecular meshwork pressure by 0.88 cmH2O for each cmH2O increase in IOP in the interval of 30-50 cmH2O. The total outflow resistance and the resistance between the anterior chamber and the tip of the microcannula was 3.91 +/- 1.53 and 1.94 +/- 0.99 cmH2O min microliter-1 respectively for the intraocular pressure interval between the spontaneous pressure and 30 cmH2O. In the interval between 30 and 45 cmH2O the corresponding figures were 2.16 +/- 0.66 and 0.20 +/- 0.13 cmH2O min microliter-1. The episcleral venous pressure at the spontaneous intraocular pressure was 14.1 +/- 1.0 cmH2O in seven animals with minimal trauma, and 12.3 +/- 0.8 cmH2O in animals after cannulation of Schlemm's canal. The outflow pressure from the anterior chamber to the episcleral veins was 4.4 +/- 1.2 cmH2O in animals with minimal trauma and 7.1 +/- 0.8 cmH2O after cannulation of Schlemm's canal. The relationship between pressures was IOP = 0.68EVP + 11.(ABSTRACT TRUNCATED AT 400 WORDS)

摘要

采用尖端直径小于5微米的套管，通过微穿刺技术研究了巩膜静脉、施莱姆管和小梁网的压力。在自发性眼压（IOP）为19.2±0.9 cmH₂O时，施莱姆管内压力（Psc）为14.3±1.0 cmH₂O。从前房到施莱姆管的流出压力为4.9±0.7 cmH₂O。压力之间的关系为IOP = 0.73Psc + 8.7。当眼压从自发水平逐步升高至30 cmH₂O时，施莱姆管内压力升高了1.7±0.6 cmH₂O，（P＜0.05）。在自发压力与高出4 - 11 cmH₂O的水平之间的眼压区间，总流出阻力以及前房与施莱姆管之间的阻力分别为3.27±0.43和2.92±0.50 cmH₂O·min·μl⁻¹。在眼压20至30 cmH₂O范围内，相应数值分别为2.89±0.45和2.69±0.42 cmH₂O·min·μl⁻¹；在25至35 cmH₂O压力范围内，分别为2.48±0.58和2.31±0.59 cmH₂O·min·μl⁻¹。在眼压低于35 cmH₂O时，总流出阻力与前房和施莱姆管之间阻力的差值约为总阻力的10%。在30至50 cmH₂O区间，眼压每升高1 cmH₂O，小梁网压力升高0.88 cmH₂O。在自发压力与30 cmH₂O之间的眼压区间，总流出阻力以及前房与微套管尖端之间的阻力分别为3.91±1.53和1.94±0.99 cmH₂O·min·μl⁻¹。在30至45 cmH₂O区间，相应数值分别为2.16±0.66和0.20±0.13 cmH₂O·min·μl⁻¹。7只轻度创伤动物的自发性眼压下巩膜静脉压为14.1±1.0 cmH₂O；施莱姆管插管后的动物为12.3±0.8 cmH₂O。轻度创伤动物从前房到巩膜静脉的流出压力为4.4±1.2 cmH₂O；施莱姆管插管后为7.1±0.8 cmH₂O。压力之间的关系为IOP = 0.68EVP + 11。（摘要截断于400字）