Johnson M C, Kamm R D
Invest Ophthalmol Vis Sci. 1983 Mar;24(3):320-5.
A mathematical model of Schlemm's canal is developed to simulate collapse of the canal and its effect on resistance to flow through the aqueous outflow network. Schlemm's canal is modeled as a porous, compliant channel that is held open by the trabecular meshwork. The trabecular meshwork is modeled as a series of linear springs that allow the inner wall of Schlemm's canal to deform in proportion to the local pressure drop across it. Based on comparisons between the model and results in the literature, the following tentative conclusions are reached: (1) Most of the resistance in the aqueous outflow network occurs in the inner wall of Schlemm's canal. (2) Glaucoma is not caused by a weakening of the trabecular meshwork and a resultant collapse of Schlemm's canal alone. Instead, glaucoma probably results from an increased flow resistance of the inner wall of the canal.
建立了施莱姆管的数学模型，以模拟该管的塌陷及其对房水流出网络中流动阻力的影响。施莱姆管被建模为一个多孔的、可顺应的通道，由小梁网保持开放。小梁网被建模为一系列线性弹簧，允许施莱姆管的内壁根据其两端的局部压降成比例地变形。基于模型与文献结果的比较，得出以下初步结论：（1）房水流出网络中的大部分阻力发生在施莱姆管的内壁。（2）青光眼并非仅由小梁网的弱化以及由此导致的施莱姆管塌陷引起。相反，青光眼可能是由管内壁流动阻力增加所致。
