Gorshkova E A, Nedospasov S A, Shilov E S
Moscow State University, Faculty of Biology, Moscow, 119992 Russia.
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia.
Mol Biol (Mosk). 2016 Nov-Dec;50(6):1039-1048. doi: 10.7868/S0026898416060069.
The IL-6 family of cytokines includes a variety of proteins that function not only within the immune system, but also in other organs, tissues, and types of cells, including neurons. The common evolutionary origin of the IL-6 family proteins determines similar mechanisms of reception and intracellular signaling, although their primary structures are highly variable, as well as their biological functions. We have demonstrated that the members of the IL-6 family have high evolutionary plasticity. This manifests in a high degree of population polymorphism for IL-6 family genes, as well as varying degrees of evolutionary conservation among members of the family. The degree of evolutionary conservation of IL-6 family proteins does not correlate with the mechanisms of interaction between these cytokines and their receptors.
白细胞介素-6（IL-6）细胞因子家族包括多种蛋白质，它们不仅在免疫系统中发挥作用，还在其他器官、组织以及包括神经元在内的各类细胞中发挥作用。IL-6家族蛋白质的共同进化起源决定了其相似的受体结合和细胞内信号传导机制，尽管它们的一级结构高度可变，生物学功能也各不相同。我们已经证明，IL-6家族成员具有高度的进化可塑性。这表现为IL-6家族基因的高度群体多态性，以及家族成员之间不同程度的进化保守性。IL-6家族蛋白质的进化保守程度与这些细胞因子及其受体之间的相互作用机制无关。
