多效性和特异性：白细胞介素 6 细胞因子家族的启示。

Pleiotropy and Specificity: Insights from the Interleukin 6 Family of Cytokines.

机构信息

Division of Molecular Psychoimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-0815, Japan.

Division of Molecular Psychoimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-0815, Japan; Headquarters, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.

出版信息

Immunity. 2019 Apr 16;50(4):812-831. doi: 10.1016/j.immuni.2019.03.027.

DOI:10.1016/j.immuni.2019.03.027

PMID:30995501

Abstract

Since the molecular cloning of interleukin-6 (IL-6) in 1986, many other cytokines have been found to share the same signal transducer, gp130, in their receptor complexes. Thus, the IL-6 family of cytokines now consists of ten members. Although some of the family members' functions are redundant as a result of the expression of gp130, there are also functional distinctions between members. The mechanisms that determine functional redundancies and distinctions are not completely understood. Yet, research has clarified the role of IL-6 family cytokines in autoimmune diseases and has led to effective therapies that target them. Here, we review the IL-6 family of cytokines in autoimmune diseases, with a particular focus on the prototypical member IL-6, from the viewpoints of their structure, signaling, and biological features and discuss possible mechanisms of their functional pleiotropy.

摘要

自 1986 年白细胞介素-6（IL-6）的分子克隆以来，许多其他细胞因子在其受体复合物中发现了相同的信号转导器 gp130。因此，IL-6 细胞因子家族现在由十个成员组成。尽管由于 gp130 的表达，一些家族成员的功能是冗余的，但成员之间也存在功能上的区别。决定功能冗余和区别的机制尚不完全清楚。然而，研究已经阐明了 IL-6 细胞因子家族在自身免疫性疾病中的作用，并导致了针对它们的有效治疗方法。在这里，我们从结构、信号转导和生物学特征的角度，综述了自身免疫性疾病中的 IL-6 细胞因子家族，特别关注典型成员 IL-6，并讨论了它们功能多效性的可能机制。