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细胞泛素与膜运输系统的整合：聚焦去泛素化酶

Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases.

作者信息

Clague Michael J, Urbé Sylvie

机构信息

Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, UK.

出版信息

FEBS J. 2017 Jun;284(12):1753-1766. doi: 10.1111/febs.14007. Epub 2017 Jan 29.

DOI:10.1111/febs.14007
PMID:28064438
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5484354/
Abstract

The cell is comprised of integrated multilevel protein networks or systems. The ubiquitin, protein homeostasis and membrane trafficking systems are highly integrated. Here, we look at the influence of reversible ubiquitylation on membrane trafficking and organelle dynamics. We review the regulation of endocytic sorting, selective autophagy and the secretory pathway by ubiquitin signals, with a particular focus on detailing the contribution of deubiquitylating enzymes.

摘要

细胞由整合的多层次蛋白质网络或系统组成。泛素、蛋白质稳态和膜运输系统高度整合。在此，我们探讨可逆泛素化对膜运输和细胞器动态的影响。我们综述了泛素信号对胞吞分选、选择性自噬和分泌途径的调控，特别着重详细阐述去泛素化酶的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0554/5484354/3ed98f098a66/FEBS-284-1753-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0554/5484354/f3cf334e3e66/FEBS-284-1753-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0554/5484354/d4b964469981/FEBS-284-1753-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0554/5484354/3ed98f098a66/FEBS-284-1753-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0554/5484354/f3cf334e3e66/FEBS-284-1753-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0554/5484354/d4b964469981/FEBS-284-1753-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0554/5484354/3ed98f098a66/FEBS-284-1753-g003.jpg

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