Ushkalova E A, Petrov A D, Shcheglova N V
Farmakol Toksikol. 1989 Jul-Aug;52(4):43-5.
In the experiments on rabbits it was shown that quinidine administered intravenously in a dose of 5 mg/kg exerts no effect on the blood coagulability but decreases the degree and duration of the anticoagulant effect of heparin. Lidocaine, trimecaine and pyromecaine at the same dose alter neither the blood coagulability nor the anticoagulant effect of heparin.
在对兔子的实验中表明,静脉注射剂量为5毫克/千克的奎尼丁对血液凝固性没有影响,但会降低肝素的抗凝效果的程度和持续时间。相同剂量的利多卡因、三甲卡因和吡咯卡因既不改变血液凝固性,也不改变肝素的抗凝效果。