[The influence of ciprofloxacin and pefloxacin on blood coagulation and the anticoagulant effect of heparin].

At a single intravenous administration to rabbits ciprofloxacin (10 and 20 mg/kg) and pefloxacin (40 mg/kg) increased the blood coagulability. Administered in a dose of 20 mg/kg pefloxacin exerted no effect on the parameter. Ciprofloxacin (20 mg/kg) and pefloxacin (40 mg/kg) decreased the anticoagulant effect of heparin (100 U/kg).