[环丙沙星和培氟沙星对血液凝固及肝素抗凝作用的影响]
[The influence of ciprofloxacin and pefloxacin on blood coagulation and the anticoagulant effect of heparin].
作者信息
Lepakhin V K, Ushkalova E A, Shcheglova N V
出版信息
Farmakol Toksikol. 1989 Sep-Oct;52(5):33-6.
PMID:2599074
Abstract
At a single intravenous administration to rabbits ciprofloxacin (10 and 20 mg/kg) and pefloxacin (40 mg/kg) increased the blood coagulability. Administered in a dose of 20 mg/kg pefloxacin exerted no effect on the parameter. Ciprofloxacin (20 mg/kg) and pefloxacin (40 mg/kg) decreased the anticoagulant effect of heparin (100 U/kg).
摘要
对兔子单次静脉注射环丙沙星（10毫克/千克和20毫克/千克）和培氟沙星（40毫克/千克）可增加血液凝固性。以20毫克/千克的剂量给药时，培氟沙星对该参数无影响。环丙沙星（20毫克/千克）和培氟沙星（40毫克/千克）可降低肝素（100单位/千克）的抗凝作用。
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