产前暴露于嘌呤拮抗剂导致的严重 T 细胞淋巴细胞减少症可通过 TREC 新生儿筛查检出。
Profound T-cell lymphopenia associated with prenatal exposure to purine antagonists detected by TREC newborn screening.
机构信息
Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, Calif.
Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, Calif.
出版信息
J Allergy Clin Immunol Pract. 2017 Jan-Feb;5(1):198-200. doi: 10.1016/j.jaip.2016.09.028.
Abstract
Recognition of non-SCID and secondary causes of T cell lymphopenia detected by TREC newborn screening is important in directing subsequent care and identifying those who would not benefit from more invasive interventions. Here, we report two infants with low TRECs and severe, but self-resolving, T cell lymphopenia identified by SCID NBS that were caused by exposure to purine antimetabolites.
摘要
通过 TREC 新生儿筛查发现的非 SCID 和继发性 T 细胞减少症的识别对于指导后续护理和确定那些不会从更具侵入性干预中获益的患者非常重要。在这里，我们报告了两名因暴露于嘌呤抗代谢物而导致 TREC 水平低且严重但可自行缓解的 T 细胞减少症的婴儿，他们均通过 SCID NBS 筛查发现。
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