Rice-Evans C, Baysal E, Singh S, Jones S A, Jones J G
Department of Biochemistry, Royal Free Hospital School of Medicine, London, England.
FEBS Lett. 1989 Oct 9;256(1-2):17-20. doi: 10.1016/0014-5793(89)81709-0.
The iron chelator desferrioxamine has been applied in many studies of pathological states by several investigators. The resulting decreases in cellular and tissue damage have been interpreted as an indication of the involvement of iron-mediated radical species. Although the nature and location of the iron species have not been identified, the assumption has often been made that desferrioxamine is able to enter cells. This paper reports investigations of the ability of desferrioxamine to cross the erythrocyte membrane in comparison with that of specific hydroxypyridone iron chelators by assessing their interaction with haemoglobin.
铁螯合剂去铁胺已被多位研究者应用于许多病理状态的研究中。由此导致的细胞和组织损伤的减轻被解释为铁介导的自由基参与的迹象。尽管尚未确定铁物种的性质和位置，但人们常常假定去铁胺能够进入细胞。本文通过评估去铁胺与血红蛋白的相互作用，报告了去铁胺与特定羟基吡啶铁螯合剂相比穿过红细胞膜能力的研究。
