镰状细胞膜与氧化损伤。
Sickle cell membranes and oxidative damage.
作者信息
Rice-Evans C, Omorphos S C, Baysal E
出版信息
Biochem J. 1986 Jul 1;237(1):265-9. doi: 10.1042/bj2370265.
Abstract
Sickle erythrocytes and their membranes are susceptible to endogenous free-radical-mediated oxidative damage which correlates with the proportion of irreversibly sickled cells. The suppression of incubation-induced oxidative stress by antioxidants, free radical scavengers and an iron chelator suggest that oxidation products of membrane-bound haemoglobin contribute towards the pathology of the disease.
摘要
镰状红细胞及其细胞膜易受内源性自由基介导的氧化损伤，这种损伤与不可逆镰状细胞的比例相关。抗氧化剂、自由基清除剂和铁螯合剂对孵育诱导的氧化应激的抑制作用表明，膜结合血红蛋白的氧化产物促成了该疾病的病理过程。
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