Bork P
Academy of Sciences of German Democratic Republic, Department of Biomathematics, Berlin.
FEBS Lett. 1989 Oct 23;257(1):191-5. doi: 10.1016/0014-5793(89)81818-6.
32 consensus patterns for a set of functional regions and structural motifs in protein sequences were constructed. The pattern definition is heuristic and based on 11 selected steric and physicochemical properties. By comparison with these patterns, it was possible to identify, without false detection, 1532 sites in 8702 protein sequences of SWISSPROT. Screening against such a pattern library offers a considerable chance to identify functional regions or structural motifs in proteins from which only the sequence is known.
构建了一组蛋白质序列中功能区域和结构基序的32种共有模式。模式定义是启发式的，基于11种选定的空间和物理化学性质。通过与这些模式进行比较，能够在不产生误检测的情况下，在SWISSPROT的8702个蛋白质序列中识别出1532个位点。针对这样一个模式库进行筛选，为识别仅知道序列的蛋白质中的功能区域或结构基序提供了相当大的机会。
