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Recognition of different nucleotide-binding sites in primary structures using a property-pattern approach.

作者信息

Bork P, Grunwald C

机构信息

Department of Biomathematics, Central Institute of Molecular Biology, Academy of Sciences of German Democratic Republic, Berlin-Buch.

出版信息

Eur J Biochem. 1990 Jul 31;191(2):347-58. doi: 10.1111/j.1432-1033.1990.tb19129.x.

DOI:10.1111/j.1432-1033.1990.tb19129.x
PMID:2384083
Abstract

Consensus sequence patterns for beta-alpha-beta folds binding FAD, NAD and GTP were constructed on the basis of 11 steric and physicochemical properties. These property patterns permit detection and distinction of the respective nucleotide-binding sites on the basis of amino acid sequence analysis alone. The SWISS-PROT database (release 9) was screened with the three calculated patterns, and nucleotide-binding sites identified are presented. They correspond to existing structure data (if known). For the detected sequence segments we are able to predict the beta-alpha-beta motif as well as the respective binding sites. For some of the proteins so detected a nucleotide-binding capacity has not previously been reported.

摘要

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