Hofmann G E, Denis A L, Scott R T, Muasher S J
Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk.
Fertil Steril. 1989 Oct;52(4):622-6. doi: 10.1016/s0015-0282(16)60975-5.
The incidence of transient hyperprolactinemia and its impact on in vitro fertilization (IVF) were determined in 151 euprolactinemic women with tubal infertility undergoing an identical gonadotropin stimulation for IVF. Prolactin (PRL) levels were measured on the morning of cycle day 3, days of human chorionic gonadotropin (hCG) administration, and peak estradiol (E2), and in the midluteal phase. Women were divided into high (H: peak E2 greater than 1,000 pg/mL, n = 51), intermediate (I:peak E2: 500 to 800 pg/mL, n = 50), or low (L:peak E2 less than 400 pg/mL, n = 50) E2 response groups. There was no difference in the incidence of hyperprolactinemia on cycle day 3 between the response groups (H:16%, I: 12%, and L:8%). However, high responders had a higher incidence of hyperprolactinemia than intermediate or low responders on all other study days. The incidence of hyperprolactinemia was greater than baseline (cycle day 3) only in the high responders on the day of peak E2. Serum prolactin was strongly correlated with peak E2 (r = 0.41). There were no differences in the number of preovulatory oocytes retrieved or fertilized or the pregnancy rates between hyperprolactinemic and euprolactinemic patients in each response group or when all hyperprolactinemic and euprolactinemic patients, regardless of E2 response, were compared. Transient hyperprolactinemia during gonadotropin stimulation for IVF occurs and correlates with E2 response but has no impact on IVF outcome.
在151名患有输卵管性不孕且催乳素水平正常的女性中，确定了促性腺激素刺激体外受精（IVF）时短暂性高催乳素血症的发生率及其对IVF的影响。在月经周期第3天早晨、注射人绒毛膜促性腺激素（hCG）当天、雌二醇（E2）峰值日以及黄体中期测量催乳素（PRL）水平。将女性分为高E2反应组（H：E2峰值大于1000 pg/mL，n = 51）、中E2反应组（I：E2峰值为500至800 pg/mL，n = 50）或低E2反应组（L：E2峰值小于400 pg/mL，n = 50）。各反应组在月经周期第3天高催乳素血症的发生率无差异（H组：16%，I组：12%，L组：8%）。然而，在所有其他研究日，高反应者的高催乳素血症发生率高于中反应者或低反应者。仅在高反应者的E2峰值日，高催乳素血症的发生率高于基线（月经周期第3天）。血清催乳素与E2峰值密切相关（r = 0.41）。在每个反应组中，高催乳素血症患者和催乳素水平正常的患者之间，以及在比较所有高催乳素血症患者和催乳素水平正常的患者（无论E2反应如何）时，排卵前回收或受精的卵母细胞数量或妊娠率均无差异。在IVF促性腺激素刺激期间会出现短暂性高催乳素血症，且与E2反应相关，但对IVF结局无影响。
