Palermo G, Devroey P, Camus M, Khan I, Wisanto A, Van Steirteghem A C
Center for Reproductive Medicine, Vrije Universiteit Brussel, Belgium.
Fertil Steril. 1989 Oct;52(4):645-9. doi: 10.1016/s0015-0282(16)60979-2.
Twenty-five infertile couples in which the male had antisperm antibodies were treated by in vitro fertilization (IVF), zygote intrafallopian transfer, or gamete intrafallopian transfer in 38 cycles. In 10 females a tubal pathology was present, and in the normal female patients repeated intrauterine insemination with husband sperm had failed. The presence of an andrological factor in 17 male patients did not influence the fertilization and the cleavage of the retrieved oocytes. Although the fertilization rate of 45.8% was significantly lower than in patients with tubal pathology, the pregnancy rate was 34.2% per started cycle and 44.8% per replacement. Furthermore, the embryos were of lesser quality than in couples with tubal and idiopathic infertility. This study suggests that IVF could be considered as a useful therapeutic approach for couples with a positive direct mixed antiglobulin reaction test before advising them the use of heterologous sperm.
25对男性存在抗精子抗体的不育夫妇接受了体外受精（IVF）、受精卵输卵管内移植或配子输卵管内移植治疗，共进行了38个周期。10名女性存在输卵管病变，正常女性患者使用丈夫精子进行的反复宫腔内人工授精均失败。17名男性患者存在男科因素，但这并未影响回收卵母细胞的受精和分裂。尽管45.8%的受精率显著低于输卵管病变患者，但起始周期的妊娠率为34.2%，每次移植的妊娠率为44.8%。此外，胚胎质量低于输卵管性和特发性不育夫妇。本研究表明，在建议使用供精之前，体外受精可被视为直接混合抗球蛋白反应试验阳性夫妇的一种有效治疗方法。
