Gross Catharina C, Schulte-Mecklenbeck Andreas, Wiendl Heinz, Marcenaro Emanuela, Kerlero de Rosbo Nicole, Uccelli Antonio, Laroni Alice
Department of Neurology, University Hospital Münster , Münster , Germany.
Centre of Excellence for Biomedical Research, University of Genova, Genova, Italy; Department of Experimental Medicine, University of Genova, Genova, Italy.
Front Immunol. 2016 Dec 19;7:606. doi: 10.3389/fimmu.2016.00606. eCollection 2016.
There is increasing evidence that natural killer (NK) cells exhibit regulatory features. Among them, CD56 NK cells have been suggested to play a major role in controlling T cell responses and maintaining homeostasis. Dysfunction in NK cell-mediated regulatory features has been recently described in untreated multiple sclerosis (MS), suggesting a contribution to MS pathogenesis. Moreover, biological disease-modifying treatments effective in MS apparently enhance the frequencies and/or regulatory function of NK cells, further pointing toward an immunoprotective role of NK cells in MS. Here, we summarize the current knowledge on the regulatory functions of NK cells, based on their interactions with other cells belonging to the innate compartment, as well as with adaptive effector cells. We review the more recent data reporting disruption of NK cell/T cell interactions in MS and discuss how disease-modifying treatments for MS affect NK cells.
越来越多的证据表明，自然杀伤（NK）细胞具有调节功能。其中，CD56 NK细胞被认为在控制T细胞反应和维持体内平衡方面发挥主要作用。最近在未经治疗的多发性硬化症（MS）中描述了NK细胞介导的调节功能障碍，提示其对MS发病机制有影响。此外，对MS有效的生物疾病修饰治疗明显提高了NK细胞的频率和/或调节功能，进一步表明NK细胞在MS中具有免疫保护作用。在此，我们基于NK细胞与先天免疫细胞以及适应性效应细胞之间的相互作用，总结了目前关于NK细胞调节功能的知识。我们回顾了最近报道MS中NK细胞/T细胞相互作用破坏的数据，并讨论了MS的疾病修饰治疗如何影响NK细胞。
