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复发缓解型多发性硬化症患者表现出不同的自然杀伤细胞功能亚群。

Relapsing-remitting multiple sclerosis patients exhibit differential natural killer functional subpopulations.

机构信息

CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6200-506, Covilhã, Portugal.

Clinical Pathology Service, Centro Hospitalar Universitário da Cova da Beira (CHUCB), Covilhã, Portugal.

出版信息

Acta Neurol Belg. 2024 Apr;124(2):603-610. doi: 10.1007/s13760-024-02488-y. Epub 2024 Mar 5.

Abstract

BACKGROUND

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) and has been known as T-cell mediated. However, the contribution of multiple cell types, notably natural killer (NK) cells, has also been reported.

AIM

To quantify circulating total NK cells and its subpopulations, CD56 dim and bright, and to characterize the functional phenotype and IFN-γ and TNF-α production in relapsing-remitting patients treated with IFN-β and in apparently healthy controls.

RESULTS

CD56 NK cells were found to be the least represented subpopulation. In relapse patients, the frequencies of IFN-γ-producing NK cells and their subpopulations were significantly decreased. In remission patients, CD56 NK cells expressed high levels of HLA-DR and CD54.

CONCLUSION

These results suggest that remission RRMS patients, although in an inactive stage of MS, present circulating NK cells with an activation phenotype, supporting the idea that NK cells may be relevant mediators in the MS pathophysiology.

摘要

背景

多发性硬化症(MS)是一种中枢神经系统(CNS)的慢性炎症性疾病,已知是由 T 细胞介导的。然而,也有报道称多种细胞类型,特别是自然杀伤(NK)细胞,也有贡献。

目的

定量检测循环总 NK 细胞及其亚群 CD56 暗区和亮区,并描述接受 IFN-β治疗的缓解-复发型患者和健康对照者 NK 细胞的功能表型以及 IFN-γ和 TNF-α的产生情况。

结果

发现 CD56 NK 细胞是最少的亚群。在复发患者中,IFN-γ产生 NK 细胞及其亚群的频率显著降低。在缓解期患者中,CD56 NK 细胞表达高水平的 HLA-DR 和 CD54。

结论

这些结果表明,尽管处于 MS 的静止期,缓解期 RRMS 患者仍存在具有激活表型的循环 NK 细胞,支持 NK 细胞可能是 MS 病理生理学中的重要介质的观点。

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