Akita Rie, Sowa Yoshihiro, Morita Daiki, Numajiri Toshiaki
Departments of Plastic and Reconstructive Surgery, Graduate School of Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Eplasty. 2016 Dec 16;16:e33. eCollection 2016.
Pigmented epithelioid melanocytoma was proposed by Zembowicz et al in 2004 including lesions previously diagnosed as human animal-type melanoma and epithelioid blue nevus. Tumors are composed of epithelioid and spindled melanocytes with heavy pigmentation. We report a case of pigmented epithelioid melanocytoma in 47-year-old Asian woman. The tumor sized 10 × 6 × 2 cm on the anterior aspect of right lower leg. On resecting surgery, we also found black pigmented lymph nodes in the groin area on harvesting skin graft. Histological examination showed a typical figure for pigmented epithelioid melanocytoma. In groin area, melanocytes were observed only in the lymph node capsule. Thus, we conclude that melanocytes in the capsule of this case could not be associated with metastasis. The patient is doing well 2 years after the surgery, with no evidence of recurrence or distant metastases. Pigmented epithelioid melanocytoma is a rare, heavily pigmented, borderline, melanocytic tumor with infiltrative borders. It has potential for frequent metastases but shows an indolent clinical course.
色素性上皮样黑素细胞瘤由曾博维茨等人于2004年提出，包括先前诊断为人畜混合型黑素瘤和上皮样蓝痣的病变。肿瘤由色素沉着严重的上皮样和梭形黑素细胞组成。我们报告一例47岁亚洲女性的色素性上皮样黑素细胞瘤。肿瘤位于右小腿前侧，大小为10×6×2厘米。在切除手术中，我们在取皮移植时还发现腹股沟区有黑色色素沉着的淋巴结。组织学检查显示为色素性上皮样黑素细胞瘤的典型表现。在腹股沟区，仅在淋巴结被膜中观察到黑素细胞。因此，我们得出结论，该病例被膜中的黑素细胞与转移无关。患者术后2年情况良好，无复发或远处转移迹象。色素性上皮样黑素细胞瘤是一种罕见的、色素沉着严重的、边界性的、具有浸润性边界的黑素细胞肿瘤。它有频繁转移的可能，但临床病程进展缓慢。
