Ridolfi R L, Rosen P P, Thaler H
Cancer. 1977 Jan;39(1):164-71. doi: 10.1002/1097-0142(197701)39:1<164::aid-cncr2820390127>3.0.co;2-t.
Aggregates of cells resembling those of cutaneous nevi have been found in the capsules of lymph nodes. Although seemingly rare, this extraordinary lesion could conceivably occur often enough to be more than a pathological curiosity, and should be differentiated from metastatic tumor. Slides from every axillary lymph node dissection for female mammary carcinoma in the years 1964 and 1974 at Memorial Hospital were reviewed, as were slides from 100 consecutive lymph node dissections performed during 1974 in patients with malignant melanoma. Nevus cell aggregates (NCA) were associated with three of 17,504 lymph nodes (0.017%) obtained from 909 mastectomies, or 0.33% of the cases. Among the 100 lymph node dissections for malignant melanoma, NCA were found associated with three of the 2,607 lymph nodes examined (0.12%), or 3.0% of the cases studied. Since NCA occur in association with lymph nodes more often than previously thought, the possibility that they may be a potential source of malignant melanoma in patients without a demonstrable cutaneous or mucosal primary is discussed.
在淋巴结被膜中发现了类似于皮肤痣细胞的细胞聚集物。尽管这种病变看似罕见，但可以想象它可能经常发生，不仅仅是一种病理上的奇闻，并且应该与转移性肿瘤相鉴别。回顾了纪念医院1964年和1974年对女性乳腺癌进行的每例腋窝淋巴结清扫的切片，以及1974年对100例恶性黑色素瘤患者连续进行淋巴结清扫的切片。在从909例乳房切除术中获取的17504个淋巴结中，有3个（0.017%）与痣细胞聚集物（NCA）相关，占病例的0.33%。在对恶性黑色素瘤进行的100例淋巴结清扫中，在所检查的2607个淋巴结中有3个（0.12%）发现与NCA相关，占所研究病例的3.0%。由于NCA与淋巴结相关的发生率比以前认为的更高，因此讨论了它们可能是没有明显皮肤或黏膜原发灶的患者中恶性黑色素瘤潜在来源的可能性。
