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Targeting tumorigenicity of breast cancer stem-like cells using combination epigenetic therapy: something old and something new.

作者信息

Huang Yi, Davidson Nancy E

机构信息

University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA;; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA;; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

出版信息

J Thorac Dis. 2016 Nov;8(11):2971-2974. doi: 10.21037/jtd.2016.11.18.

DOI:10.21037/jtd.2016.11.18
PMID:28066560
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5179425/
Abstract
摘要

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本文引用的文献

1
Epigenetics: Separate paths for epigenomes and genomes in cancer evolution?表观遗传学：癌症演变中表观基因组和基因组的不同路径？
Nat Rev Genet. 2016 Jul 15;17(8):438. doi: 10.1038/nrg.2016.89.
2
Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor Growth.DNA甲基转移酶（DNMT）和组蛋白去乙酰化酶（HDAC）的联合抑制可阻断癌症干细胞样细胞的致瘤性并减弱乳腺肿瘤生长。
Cancer Res. 2016 Jun 1;76(11):3224-35. doi: 10.1158/0008-5472.CAN-15-2249. Epub 2016 Apr 5.
3
Inhibition of histone deacetylases in cancer therapy: lessons from leukaemia.组蛋白去乙酰化酶抑制在癌症治疗中的应用：白血病的启示
Br J Cancer. 2016 Mar 15;114(6):605-11. doi: 10.1038/bjc.2016.36. Epub 2016 Feb 23.
4
Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders.组蛋白去乙酰化酶及其抑制剂在癌症、神经疾病和免疫紊乱中的作用。
Nat Rev Drug Discov. 2014 Sep;13(9):673-91. doi: 10.1038/nrd4360. Epub 2014 Aug 18.
5
Brief reports: A distinct DNA methylation signature defines breast cancer stem cells and predicts cancer outcome.短篇报道：独特的 DNA 甲基化特征定义了乳腺癌干细胞，并预测了癌症结局。
Stem Cells. 2014 Nov;32(11):3031-6. doi: 10.1002/stem.1792.
6
Epigenetic reprogramming in breast cancer: from new targets to new therapies.乳腺癌中的表观遗传重编程：从新靶点到新疗法。
Ann Med. 2014 Sep;46(6):397-408. doi: 10.3109/07853890.2014.923740. Epub 2014 Jul 24.
7
The histone deacetylase inhibitor abexinostat induces cancer stem cells differentiation in breast cancer with low Xist expression.组蛋白去乙酰化酶抑制剂 abexinostat 可诱导低 Xist 表达的乳腺癌中的癌症干细胞分化。
Clin Cancer Res. 2013 Dec 1;19(23):6520-31. doi: 10.1158/1078-0432.CCR-13-0877. Epub 2013 Oct 18.
8
Biomarker modulation following short-term vorinostat in women with newly diagnosed primary breast cancer.短期伏立诺他治疗新诊断原发性乳腺癌女性患者后的生物标志物变化。
Clin Cancer Res. 2013 Jul 15;19(14):4008-16. doi: 10.1158/1078-0432.CCR-13-0033. Epub 2013 May 29.
9
DNA methylation profiling in the clinic: applications and challenges.临床 DNA 甲基化分析：应用与挑战。
Nat Rev Genet. 2012 Oct;13(10):679-92. doi: 10.1038/nrg3270. Epub 2012 Sep 4.
10
Targeting epigenetic readers in cancer.靶向癌症中的表观遗传阅读器
N Engl J Med. 2012 Aug 16;367(7):647-57. doi: 10.1056/NEJMra1112635.