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Dexmedetomidine: magic bullet or firing blanks?

作者信息

Sellers Daniel, Djaiani George

机构信息

Department of Anesthesia and Pain Management, Toronto General Hospital, University of Toronto, Toronto, Canada.

出版信息

J Thorac Dis. 2016 Nov;8(11):3024-3027. doi: 10.21037/jtd.2016.11.34.

DOI:10.21037/jtd.2016.11.34
PMID:28066574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5179421/
Abstract
摘要

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本文引用的文献

1
Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial.右美托咪定预防非心脏手术后老年患者谵妄:一项随机、双盲、安慰剂对照试验。
Lancet. 2016 Oct 15;388(10054):1893-1902. doi: 10.1016/S0140-6736(16)30580-3. Epub 2016 Aug 16.
2
Dexmedetomidine versus Propofol Sedation Reduces Delirium after Cardiac Surgery: A Randomized Controlled Trial.右美托咪定与丙泊酚镇静对减少心脏手术后谵妄的作用:一项随机对照试验
Anesthesiology. 2016 Feb;124(2):362-8. doi: 10.1097/ALN.0000000000000951.
3
The use of intravenous infusion or single dose of low-dose ketamine for postoperative analgesia: a review of the current literature.静脉输注或单剂量低剂量氯胺酮用于术后镇痛:当前文献综述
Pain Med. 2015 Feb;16(2):383-403. doi: 10.1111/pme.12619. Epub 2014 Dec 19.
4
Pre-Operative, High-IL-6 Blood Level is a Risk Factor of Post-Operative Delirium Onset in Old Patients.术前高白细胞介素-6 血水平是老年患者术后谵妄发作的危险因素。
Front Endocrinol (Lausanne). 2014 Oct 17;5:173. doi: 10.3389/fendo.2014.00173. eCollection 2014.
5
Dexmedetomidine controls systemic cytokine levels through the cholinergic anti-inflammatory pathway.右美托咪定通过胆碱能抗炎途径控制全身细胞因子水平。
Inflammation. 2014 Oct;37(5):1763-70. doi: 10.1007/s10753-014-9906-1.
6
Tumours of the thymus: a cohort study of prognostic factors from the European Society of Thoracic Surgeons database.胸腺肿瘤:一项基于欧洲心胸外科医师协会数据库的预后因素队列研究
Eur J Cardiothorac Surg. 2014 Sep;46(3):361-8. doi: 10.1093/ejcts/ezt649. Epub 2014 Jan 30.
7
The neuroinflammatory response of postoperative cognitive decline.术后认知功能障碍的神经炎症反应。
Br Med Bull. 2013;106(1):161-78. doi: 10.1093/bmb/ldt006. Epub 2013 Apr 4.
8
Memory deficits induced by inflammation are regulated by α5-subunit-containing GABAA receptors.炎症引起的记忆缺陷受 α5 亚基包含的 GABA A 受体调节。
Cell Rep. 2012 Sep 27;2(3):488-96. doi: 10.1016/j.celrep.2012.08.022. Epub 2012 Sep 20.
9
Dexmedetomidine attenuates lipopolysaccharide-induced proinflammatory response in primary microglia.右美托咪定减轻原代小胶质细胞脂多糖诱导的促炎反应。
J Surg Res. 2013 Jan;179(1):e219-25. doi: 10.1016/j.jss.2012.05.047. Epub 2012 Jun 1.
10
Inhibition of α5 γ-Aminobutyric acid type A receptors restores recognition memory after general anesthesia.α5 γ-氨基丁酸 A 型受体抑制作用可恢复全麻后识别记忆
Anesth Analg. 2012 Apr;114(4):845-55. doi: 10.1213/ANE.0b013e31824720da. Epub 2012 Mar 1.