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Did dose escalated radiotherapy in stage III non-small cell lung cancer improve overall survival?III期非小细胞肺癌中剂量递增放疗是否能提高总生存期?
J Thorac Dis. 2016 Nov;8(11):3338-3342. doi: 10.21037/jtd.2016.11.13.
2
Improved survival with dose-escalated radiotherapy in stage III non-small-cell lung cancer: analysis of the National Cancer Database.剂量递增放疗改善 III 期非小细胞肺癌患者的生存:国家癌症数据库分析。
Ann Oncol. 2016 Oct;27(10):1887-94. doi: 10.1093/annonc/mdw276. Epub 2016 Aug 8.
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本文引用的文献

1
Improved survival with dose-escalated radiotherapy in stage III non-small-cell lung cancer: analysis of the National Cancer Database.剂量递增放疗改善 III 期非小细胞肺癌患者的生存:国家癌症数据库分析。
Ann Oncol. 2016 Oct;27(10):1887-94. doi: 10.1093/annonc/mdw276. Epub 2016 Aug 8.
2
Cancer statistics in China, 2015.《中国癌症统计数据 2015》
CA Cancer J Clin. 2016 Mar-Apr;66(2):115-32. doi: 10.3322/caac.21338. Epub 2016 Jan 25.
3
A meta-analysis comparing hyperfractionated vs. conventional fractionated radiotherapy in non-small cell lung cancer.一项比较超分割放疗与常规分割放疗用于非小细胞肺癌的荟萃分析。
J Thorac Dis. 2015 Mar;7(3):478-85. doi: 10.3978/j.issn.2072-1439.2015.02.20.
4
Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study.标准剂量与高剂量适形放疗联合并巩固使用卡铂加紫杉醇,联合或不联合西妥昔单抗治疗IIIA期或IIIB期非小细胞肺癌患者(RTOG 0617):一项随机、二乘二析因3期研究。
Lancet Oncol. 2015 Feb;16(2):187-99. doi: 10.1016/S1470-2045(14)71207-0. Epub 2015 Jan 16.
5
Hyperfractionated and accelerated radiotherapy in non-small cell lung cancer.非小细胞肺癌的超分割加速放疗
J Thorac Dis. 2014 Apr;6(4):328-35. doi: 10.3978/j.issn.2072-1439.2013.11.06.
6
Sequential vs. concurrent chemoradiation for stage III non-small cell lung cancer: randomized phase III trial RTOG 9410.序贯与同步放化疗治疗 III 期非小细胞肺癌:RTOG9410 随机 III 期试验
J Natl Cancer Inst. 2011 Oct 5;103(19):1452-60. doi: 10.1093/jnci/djr325. Epub 2011 Sep 8.
7
Randomized phase II trial of induction chemotherapy followed by concurrent chemotherapy and dose-escalated thoracic conformal radiotherapy (74 Gy) in stage III non-small-cell lung cancer: CALGB 30105.III期非小细胞肺癌诱导化疗后序贯同步化疗及剂量递增的胸部适形放疗(74 Gy)的随机II期试验:CALGB 30105
J Clin Oncol. 2008 May 20;26(15):2457-63. doi: 10.1200/JCO.2007.14.7371.
8
The National Cancer Data Base: a powerful initiative to improve cancer care in the United States.国家癌症数据库:一项改善美国癌症护理的有力举措。
Ann Surg Oncol. 2008 Mar;15(3):683-90. doi: 10.1245/s10434-007-9747-3. Epub 2008 Jan 9.
9
Results of a Phase I trial of concurrent chemotherapy and escalating doses of radiation for unresectable non-small-cell lung cancer.不可切除非小细胞肺癌同步化疗及递增剂量放疗的I期试验结果
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10
High-dose radiation improved local tumor control and overall survival in patients with inoperable/unresectable non-small-cell lung cancer: long-term results of a radiation dose escalation study.高剂量放疗改善了不可手术/无法切除的非小细胞肺癌患者的局部肿瘤控制和总生存期:一项放疗剂量递增研究的长期结果
Int J Radiat Oncol Biol Phys. 2005 Oct 1;63(2):324-33. doi: 10.1016/j.ijrobp.2005.02.010.

III期非小细胞肺癌中剂量递增放疗是否能提高总生存期?

Did dose escalated radiotherapy in stage III non-small cell lung cancer improve overall survival?

作者信息

Wang Wei-Wei, Wang Shao-Jia, Zhou Zhi-Rui

机构信息

Department of Chest Surgery, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming 650031, China;; Department of Oncology, Kunming Medical University, Kunming 650031, China.

Department of Oncology, Kunming Medical University, Kunming 650031, China;; Department of Gynecological Oncology, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming 650031, China.

出版信息

J Thorac Dis. 2016 Nov;8(11):3338-3342. doi: 10.21037/jtd.2016.11.13.

DOI:10.21037/jtd.2016.11.13
PMID:28066615
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5179433/
Abstract

Radiotherapy has been applied in the treatment for lung cancer patients for many years, especially those with advanced stage disease who cannot be treated with surgery. However, if these advanced stage patients should be treated with standard dosage therapy (60 Gy) or high dosage therapy (>60 Gy) remains a hot debated point. Literature related to this topic would be reviewed here. We believe standard dosage therapy should be strongly recommended, and high dosage therapy might benefit patients with high risk factors patients.

摘要

放射疗法已应用于肺癌患者的治疗多年,尤其是那些患有晚期疾病且无法进行手术治疗的患者。然而,这些晚期患者应该接受标准剂量治疗(60 Gy)还是高剂量治疗(>60 Gy)仍是一个备受争议的热点问题。本文将对与此主题相关的文献进行综述。我们认为应强烈推荐标准剂量治疗,而高剂量治疗可能使具有高危因素的患者受益。