Dai Wangshu, Zhu Hongcheng, Chen Guangzong, Gu Hao, Gu Yihang, Sun Xinchen, Zeng Xiaoning
Department of Respiratory & Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China;; Department of Radiation Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Department of Radiation Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
J Thorac Dis. 2016 Nov;8(11):E1450-E1454. doi: 10.21037/jtd.2016.11.11.
Brain metastasis is an inauspicious consequence of lung cancer. However, the majority of cancer cells that seep into the brain died of unknown causes, only a few survived and developed into metastatic brain tumor. Communication between cancer cells and host tissue is viewed as an essential event during metastasis, but little is known about the accurate control of this processes. Within the lesion of brain metastasis, abundant activated astrocytes are observed with lung cancer cells. Previous studies have demonstrated that the astrocyte network served a protective role in the central nervous system (CNS) and most malignant cells that seep into the brain perish were rejected by astrocytes. Reactive astrocytes generated protease plasmin and cytotoxic cytokines as a defense against metastatic invasion. But recently, other investigators argued that tumor cells interactions with astrocytes promote the progression of brain metastases and protect them from the cytotoxic effects of chemotherapy. In this article, we review the architecture between astrocytes and infiltrated cancer cells, and raise a future perspective on therapeutic potential of targeting crosstalk modulators against brain metastasis.
脑转移是肺癌的一个不祥后果。然而，大多数渗入大脑的癌细胞死于不明原因，只有少数存活并发展成转移性脑肿瘤。癌细胞与宿主组织之间的通讯被视为转移过程中的一个重要事件，但对这一过程的精确控制却知之甚少。在脑转移病灶内，可观察到大量活化的星形胶质细胞与肺癌细胞并存。先前的研究表明，星形胶质细胞网络在中枢神经系统（CNS）中起保护作用，大多数渗入大脑的恶性细胞会被星形胶质细胞排斥而死亡。反应性星形胶质细胞产生蛋白酶纤溶酶和细胞毒性细胞因子以抵御转移性侵袭。但最近，其他研究者认为肿瘤细胞与星形胶质细胞的相互作用促进了脑转移的进展，并保护它们免受化疗的细胞毒性作用。在本文中，我们综述了星形胶质细胞与浸润癌细胞之间的结构关系，并对靶向串扰调节剂治疗脑转移的潜在前景提出了展望。
