Reina Simona, Guarino Francesca, Magrì Andrea, De Pinto Vito
Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy; National Institute of Biostructures and Biosystems (INBB), Rome, Italy.
Front Oncol. 2016 Dec 23;6:264. doi: 10.3389/fonc.2016.00264. eCollection 2016.
VDAC3 is the least known isoform of the mammalian voltage-dependent anion selective channels of the outer mitochondrial membrane. It has been recently shown that cysteine residues of VDAC3 are found over-oxidized. The VDAC3 cysteine over-oxidation was associated with the oxidizing environment and the abundance of reactive oxygen species (ROS) in the intermembrane space. In this work, we have examined the role of VDAC3 in general pathogenic mechanisms at the basis of mitochondrial dysfunction and involving the mitochondrial quality control. Many of the diseases reported here, including cancer and viral infections, are often associated with significant changes in the intracellular redox state. In this sense, VDAC3 bearing oxidative modifications could become marker of the oxidative load in the mitochondria and part of the ROS signaling pathway.
VDAC3是线粒体外膜上哺乳动物电压依赖性阴离子选择性通道中了解最少的亚型。最近研究表明，VDAC3的半胱氨酸残基存在过度氧化现象。VDAC3半胱氨酸的过度氧化与线粒体外膜间隙的氧化环境和活性氧（ROS）的丰度有关。在这项研究中，我们探讨了VDAC3在基于线粒体功能障碍并涉及线粒体质量控制的一般致病机制中的作用。这里报道的许多疾病，包括癌症和病毒感染，通常都与细胞内氧化还原状态的显著变化有关。从这个意义上说，带有氧化修饰的VDAC3可能成为线粒体氧化负荷的标志物以及ROS信号通路的一部分。
