Arutiunian N A, Sekretareva E V, Savchenko O N, Proĭmina F I
Fiziol Zh SSSR Im I M Sechenova. 1989 Jul;75(7):992-1002.
The concentration of the estradiol and progesterone receptors in cytosol increased within a week after ovariectomy in rats, the nucleic concentration of receptors sharply diminishing. The uterus atrophy following ovariectomy in associated with a reduction of both nucleic and cytosol receptors in the organ. Administration of estradiol (1 mg) restored the organ mass and the character of hormonal reception within a week. Progesterone and clomyphen exerted some uterotropic effect. Ovariectomy reduced the creatinkinase activity by 2.9 times and the peroxydase activity by 13 times. Two types of synthesis of female sex hormones receptors seem to exist in the rat uterus: the constitutional type depending on no hormonal effects and the induced one depending on the sex steroids, estradiol in particular.
大鼠卵巢切除术后一周内，胞质中雌二醇和孕酮受体浓度增加，而受体的核酸浓度急剧下降。卵巢切除术后子宫萎缩与该器官中核酸和胞质受体的减少有关。给予雌二醇（1毫克）可在一周内恢复器官质量和激素接受特性。孕酮和氯米芬发挥了一定的促子宫生长作用。卵巢切除术使肌酸激酶活性降低2.9倍，过氧化物酶活性降低13倍。大鼠子宫中似乎存在两种类型的雌性激素受体合成：一种是不依赖激素作用的组成型，另一种是依赖性类固醇尤其是雌二醇的诱导型。
