三氯异氰尿酸促进烯丙基肟的串联环化/三氟甲基化反应：三氟甲基异噁唑啉的合成。
Trichloroisocyanuric Acid Promoted Cascade Cyclization/Trifluoromethylation of Allylic Oximes: Synthesis of Trifluoromethylated Isoxazolines.
机构信息
College of Chemistry and Chemical Engineering, Northwest Normal University , 967 Anning East Road, Lanzhou 730070, P. R. China.
State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.
出版信息
Org Lett. 2017 Jan 20;19(2):376-379. doi: 10.1021/acs.orglett.6b03582. Epub 2017 Jan 9.
PMID:28067052
Abstract
Cheap and commercially available trichloroisocyanuric acid has been used to promote trifluoromethylation by using TMSCF as the trifluoromethyl source. The method provides a novel and efficient protocol for the construction of CF-containing 4,5-dihydroisoxazoles from allylic oximes in good to excellent yields.
摘要
廉价且市售的三氯异氰尿酸已被用于通过使用 TMSCF 作为三氟甲基源来促进三氟甲基化。该方法为从烯丙基肟构建含 CF 的 4,5-二氢异恶唑提供了一种新颖且有效的方案，产率良好至优秀。
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