Zhi Sanjun, Ma Xiaoming, Zhang Wei
Jiangsu Key Laboratory for the Chemistry of Low-Dimensional Materials, Huaiyin Normal University, 111 Changjiang West Road, Huaian 223300, China.
School of Pharmacy, Changzhou University, 1 Gehu Road, Changzhou 213164, China.
Molecules. 2024 May 29;29(11):2559. doi: 10.3390/molecules29112559.
Radical reactions are powerful in the synthesis of diverse molecular scaffolds bearing functional groups. In previous review articles, we have presented 1,2-difunctionalizations, remote 1,3-, 1,4-, 1,5-, 1,6- and 1,7-difunctionalizations, and addition followed by cyclization reactions. Presented in this paper is radical cyclization followed by the second functionalization reaction. The second functionalization could be realized by atom transfer reactions, radical or transition metal-assisted coupling reactions, and reactions with neutral molecules, cationic and anionic species.
自由基反应在合成带有官能团的各种分子骨架方面具有强大作用。在之前的综述文章中，我们介绍了1,2-双官能化、远程1,3-、1,4-、1,5-、1,6-和1,7-双官能化，以及加成后环化反应。本文介绍的是自由基环化后进行的第二次官能化反应。第二次官能化可通过原子转移反应、自由基或过渡金属辅助的偶联反应以及与中性分子、阳离子和阴离子物种的反应来实现。
