Bennebroek Gravenhorst J, Kanhai H H, Meerman R H, Ruys J H, Eernisse J G, Stroes T J, van Nieuwaal K
Department of Obstetrics and Gynecology, University Hospital Leiden, The Netherlands.
Eur J Obstet Gynecol Reprod Biol. 1989 Oct;33(1):71-7. doi: 10.1016/0028-2243(89)90080-4.
Over a period of 22 years, 154 fetuses were treated with 270 intra-uterine intraperitoneal transfusions. The patients were divided into three groups, according to the period they were treated. The overall percentage of surviving infants increased from 33% during the first period to 58% in the last period. In the group of infants that were not hydropic at the time of the first transfusion, the survival rate increased from 35 to 83%. In the group of children that were hydropic during the first transfusion, the survival rate during the first and last period was 24 and 42%, respectively. The percentage of fetuses that needed their first transfusion before the 26th week of pregnancy increased from 15 to 32% during the study period. Only 13% of these children survived. Lately, the intravascular approach has been introduced. Intravascular transfusions seem to be very effective, especially in early pregnancies and in hydropic fetuses. Application of the two techniques each in the most appropriate situation might offer optimal results for the near future.
在22年的时间里，154例胎儿接受了270次宫内腹腔输血。根据治疗时期，将患者分为三组。存活婴儿的总体百分比从第一阶段的33%增加到最后阶段的58%。在首次输血时未出现水肿的婴儿组中，存活率从35%提高到83%。在首次输血时出现水肿的儿童组中，第一阶段和最后阶段的存活率分别为24%和42%。在研究期间，需要在妊娠26周前进行首次输血的胎儿百分比从15%增加到32%。这些儿童中只有13%存活。最近，血管内输血方法已经引入。血管内输血似乎非常有效，尤其是在早期妊娠和水肿胎儿中。在最合适的情况下分别应用这两种技术可能会在不久的将来提供最佳结果。
