Liu F-Y, Liu Y-F, Yang Y, Luo Z-W, Xiang J-W, Chen Z-G, Qi R-L, Yang T-H, Xiao Y, Qing W-J, Li D W-C
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, #54 Xianlie South Road, Guangzhou, Guangdong 510060,. China.
Curr Mol Med. 2017;16(10):893-899. doi: 10.2174/1566524017666170109125256.
Since the discovery of SUMOs (small ubiquitin-like modifiers) over 20 years ago, sumoylation has recently emerged as an important posttranslational modification involved in almost all aspects of cellular physiology. In neurons, sumoylation dynamically modulates protein function and consequently plays an important role in neuronal maturation, synapse formation and plasticity. Thus, the dysfunction of sumoylation pathway is associated with many different neurological disorders. Hundreds of different proteins implicated in the pathogenesis of neurological disorders are SUMO-modified, indicating the importance of sumoylation involved in the neurological diseases. In this review, we summarize the growing findings on protein sumoylation in neuronal function and dysfunction. It is essential to have a thorough understanding on the mechanism how sumoylation contributes to neurological diseases in developing efficient therapy for these diseases.
自20多年前发现小泛素样修饰物（SUMOs）以来，SUMO化最近已成为一种重要的翻译后修饰，几乎涉及细胞生理学的各个方面。在神经元中，SUMO化动态调节蛋白质功能，因此在神经元成熟、突触形成和可塑性中发挥重要作用。因此，SUMO化途径的功能障碍与许多不同的神经疾病有关。数百种与神经疾病发病机制相关的不同蛋白质被SUMO修饰，这表明SUMO化在神经疾病中的重要性。在本综述中，我们总结了关于蛋白质SUMO化在神经元功能和功能障碍方面不断增加的研究结果。在开发针对这些疾病的有效治疗方法时，全面了解SUMO化如何导致神经疾病的机制至关重要。
